3pbl

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{{Seed}}
 
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[[Image:3pbl.png|left|200px]]
 
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==Structure of the human dopamine D3 receptor in complex with eticlopride==
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The line below this paragraph, containing "STRUCTURE_3pbl", creates the "Structure Box" on the page.
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<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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{{STRUCTURE_3pbl| PDB=3pbl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are observed. Docking of R-22, a D3R-selective antagonist, reveals an extracellular extension of the eticlopride binding site that comprises a second binding pocket for the aryl amide of R-22, which differs between the highly homologous D2R and D3R. This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications.
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===Structure of the human dopamine D3 receptor in complex with eticlopride===
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Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.,Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC Science. 2010 Nov 19;330(6007):1091-5. PMID:21097933<ref>PMID:21097933</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pbl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dopamine receptor|Dopamine receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21097933 is the PubMed ID number.
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*[[Dopamine receptor 3D structures|Dopamine receptor 3D structures]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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{{ABSTRACT_PUBMED_21097933}}
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*[[Neurotransmitters|Neurotransmitters]]
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== References ==
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==About this Structure==
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<references/>
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3PBL is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Escherichia virus T4]]
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<ref group="xtra">PMID:21097933</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Homo sapiens, enterobacteria phage t4]]
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[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Cherezov V]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
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[[Category: Chien EYT]]
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[[Category: Cherezov, V.]]
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[[Category: Han GW]]
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[[Category: Chien, E Y.T.]]
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[[Category: Katritch V]]
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[[Category: Han, G W.]]
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[[Category: Liu W]]
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[[Category: Katritch, V.]]
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[[Category: Stevens RC]]
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[[Category: Liu, W.]]
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[[Category: Zhao Q]]
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[[Category: Stevens, R C.]]
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[[Category: Zhao, Q.]]
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[[Category: 7tm]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Atcg3d]]
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[[Category: Chimera]]
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[[Category: Dopamine]]
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[[Category: Eticlopride]]
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[[Category: G protein-coupled receptor]]
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[[Category: Gpcr]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Membrane protein]]
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[[Category: Neurotransmitter]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Signal transduction]]
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[[Category: Structural genomic]]
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[[Category: T4l fusion]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:12:03 2010''
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Current revision

Structure of the human dopamine D3 receptor in complex with eticlopride

PDB ID 3pbl

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