3oll

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{{Seed}}
 
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[[Image:3oll.png|left|200px]]
 
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==Crystal structure of phosphorylated estrogen receptor beta ligand binding domain==
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The line below this paragraph, containing "STRUCTURE_3oll", creates the "Structure Box" on the page.
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<StructureSection load='3oll' size='340' side='right'caption='[[3oll]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3oll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OLL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_3oll| PDB=3oll | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oll OCA], [https://pdbe.org/3oll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oll RCSB], [https://www.ebi.ac.uk/pdbsum/3oll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oll ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref> <ref>PMID:7481822</ref> <ref>PMID:9223431</ref> <ref>PMID:9296499</ref> <ref>PMID:9223281</ref> <ref>PMID:10449719</ref> <ref>PMID:12954634</ref>
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===Crystal structure of phosphorylated estrogen receptor beta ligand binding domain===
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3OLL is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OLL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:20922740</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brunsveld, L.]]
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[[Category: Large Structures]]
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[[Category: Moecklinghoff, S.]]
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[[Category: Brunsveld L]]
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[[Category: Ottmann, C.]]
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[[Category: Moecklinghoff S]]
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[[Category: Rose, R.]]
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[[Category: Ottmann C]]
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[[Category: Hormone receptor-activator complex]]
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[[Category: Rose R]]
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[[Category: Phosphorylation]]
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[[Category: Steroid binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:20:17 2010''
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Current revision

Crystal structure of phosphorylated estrogen receptor beta ligand binding domain

PDB ID 3oll

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