2kxn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA== | |
| - | + | <StructureSection load='2kxn' size='340' side='right'caption='[[2kxn]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxn OCA], [https://pdbe.org/2kxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxn RCSB], [https://www.ebi.ac.uk/pdbsum/2kxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxn ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRA2B_HUMAN TRA2B_HUMAN] Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.<ref>PMID:9546399</ref> <ref>PMID:12165565</ref> <ref>PMID:12761049</ref> <ref>PMID:15009664</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allain FH-T]] | ||
| + | [[Category: Benderska N]] | ||
| + | [[Category: Clery A]] | ||
| + | [[Category: Dominguez C]] | ||
| + | [[Category: Jayne S]] | ||
| + | [[Category: Stamm S]] | ||
Current revision
NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA
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Categories: Homo sapiens | Large Structures | Allain FH-T | Benderska N | Clery A | Dominguez C | Jayne S | Stamm S
