3arn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3arn is ON HOLD Authors: Chong, K.T., Miyahara, S., Miyakoshi, H., Fukuoka, M. Description: Human dUTPase in complex with novel uracil derivative ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human dUTPase in complex with novel uracil derivative== | |
| + | <StructureSection load='3arn' size='340' side='right'caption='[[3arn]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3arn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSJ:N-{5-[(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHOXY]-2-METHYLPENTAN-2-YL}BENZENESULFONAMIDE'>MSJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3arn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3arn OCA], [https://pdbe.org/3arn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3arn RCSB], [https://www.ebi.ac.uk/pdbsum/3arn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3arn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[DUTPase 3D structures|DUTPase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chong KT]] | ||
| + | [[Category: Fukuoka M]] | ||
| + | [[Category: Miyahara S]] | ||
| + | [[Category: Miyakoshi H]] | ||
Current revision
Human dUTPase in complex with novel uracil derivative
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