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3aqg

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{{Seed}}
 
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[[Image:3aqg.jpg|left|200px]]
 
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==Crystal structure of human pancreatic secretory protein ZG16b==
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The line below this paragraph, containing "STRUCTURE_3aqg", creates the "Structure Box" on the page.
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<StructureSection load='3aqg' size='340' side='right'caption='[[3aqg]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3aqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3aqg| PDB=3aqg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqg OCA], [https://pdbe.org/3aqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aqg RCSB], [https://www.ebi.ac.uk/pdbsum/3aqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZG16B_HUMAN ZG16B_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ZG16p is a secretory protein that mediates condensation-sorting of pancreatic enzymes to the zymogen granule membrane in pancreatic acinar cells. ZG16p interacts with glycosaminoglycans and the binding is considered to be important for condensation-sorting of pancreatic enzymes. ZG16b/PAUF, a paralog of ZG16p, has recently been found to play a role in gene regulation and cancer metastasis. However, the detailed functions of ZG16p and ZG16b remain to be clarified. Here, in order to obtain insights into structure-function relationships, we conducted crystallographic studies of human ZG16p lectin as well as its paralog, ZG16b, and determined their crystal structures at 1.65 and 2.75A resolution, respectively. ZG16p has a Jacalin-related beta-prism fold, the first to be reported among mammalian lectins. The putative sugar-binding site of ZG16p is occupied by a glycerol molecule, mimicking the mannose bound to Jacalin-related mannose-binding-type plant lectins such as Banlec. ZG16b also has a beta-prism fold, but some amino acid residues of the putative sugar-binding site differ from those of the mannose-type binding site suggesting altered preference. A positively charged patch, which may bind sulfated groups of the glycosaminoglycans, is located around the putative sugar-binding site of ZG16p and ZG16b. Taken together, we suggest that the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site.
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===Crystal structure of a hypothetical protein II from human pancreatic cell===
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Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold.,Kanagawa M, Satoh T, Ikeda A, Nakano Y, Yagi H, Kato K, Kojima-Aikawa K, Yamaguchi Y Biochem Biophys Res Commun. 2010 Nov 24. PMID:21110947<ref>PMID:21110947</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21110947}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3aqg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21110947 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21110947}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3AQG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQG OCA].
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==Reference==
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<ref group="xtra">PMID:21110947</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kanagawa, M.]]
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[[Category: Large Structures]]
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[[Category: Kojima-Aikawa, K.]]
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[[Category: Kanagawa M]]
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[[Category: Nakano, Y.]]
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[[Category: Kojima-Aikawa K]]
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[[Category: Satoh, T.]]
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[[Category: Nakano Y]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Satoh T]]
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[[Category: Beta-prism fold]]
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[[Category: Yamaguchi Y]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:47:21 2010''
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Current revision

Crystal structure of human pancreatic secretory protein ZG16b

PDB ID 3aqg

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