2v5z

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[[Image:2v5z.gif|left|200px]]<br /><applet load="2v5z" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2v5z, resolution 1.60&Aring;" />
 
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'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE'''<br />
 
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==Overview==
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==Structure of human MAO B in complex with the selective inhibitor safinamide==
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Structures of human monoamine oxidase B (MAO B) in complex with safinamide, and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively, inhibit MAO B with Ki values in the 0.1-0.5 muM range that are 30-700-fold, lower than those observed with MAO A. The inhibitors bind noncovalently to, MAO B, occupying both the entrance and the substrate cavities and showing, a similarly oriented benzyloxy substituent.
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<StructureSection load='2v5z' size='340' side='right'caption='[[2v5z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SAG:(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]'>SAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5z OCA], [https://pdbe.org/2v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5z RCSB], [https://www.ebi.ac.uk/pdbsum/2v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5z ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2V5Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=SAG:'>SAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] Known structural/functional Sites: <scene name='pdbsite=AC1:Fad Binding Site For Chain A'>AC1</scene>, <scene name='pdbsite=AC2:Sag Binding Site For Chain A'>AC2</scene>, <scene name='pdbsite=AC3:Fad Binding Site For Chain B'>AC3</scene> and <scene name='pdbsite=AC4:Sag Binding Site For Chain B'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5Z OCA].
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*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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==Reference==
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</StructureSection>
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Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Oct 4;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17915852 17915852]
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[[Category: Amine oxidase (flavin-containing)]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Binda, C.]]
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[[Category: Binda C]]
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[[Category: Caccia, C.]]
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[[Category: Caccia C]]
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[[Category: Carotti, A.]]
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[[Category: Carotti A]]
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[[Category: Edmondson, D.E.]]
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[[Category: Edmondson DE]]
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[[Category: Mattevi, A.]]
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[[Category: Mattevi A]]
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[[Category: Pisani, L.]]
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[[Category: Pisani L]]
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[[Category: Salvati, P.]]
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[[Category: Salvati P]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: FAD]]
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[[Category: SAG]]
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[[Category: fad]]
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[[Category: flavoprotein]]
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[[Category: human mao b structure]]
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[[Category: membrane]]
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[[Category: mitochondrion]]
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[[Category: neuroprotection]]
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[[Category: oxidoreductase]]
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[[Category: parkinson's disease]]
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[[Category: reversible inhibitor binding]]
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[[Category: safinamide]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:07:22 2008''
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Current revision

Structure of human MAO B in complex with the selective inhibitor safinamide

PDB ID 2v5z

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