2l73

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'''Unreleased structure'''
 
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The entry 2l73 is ON HOLD until Paper Publication
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==Structure of the NOXO1b PX domain==
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<StructureSection load='2l73' size='340' side='right'caption='[[2l73]]' scene=''>
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Authors: Davis, N.Y., McPhail, L.C., Horita, D.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [https://pdbe.org/2l73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [https://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:15:57 2010''
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Davis NY]]
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[[Category: Horita DA]]
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[[Category: McPhail LC]]

Current revision

Structure of the NOXO1b PX domain

PDB ID 2l73

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