2xzb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Pig Gastric H,K-ATPase with bound BeF and SCH28080== | |
| + | <StructureSection load='2xzb' size='340' side='right'caption='[[2xzb]], [[Resolution|resolution]] 7.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2xzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 7Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzb OCA], [https://pdbe.org/2xzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xzb RCSB], [https://www.ebi.ac.uk/pdbsum/2xzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xzb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Acid-related gastric diseases are associated with disorder of digestive tract acidification. The gastric proton pump, H(+),K(+)-ATPase, exports H(+) in exchange for luminal K(+) to generate a highly acidic environment in the stomach, and is a main target for acid suppressants. Here, we report the three-dimensional structure of gastric H(+),K(+)-ATPase with bound SCH28080, a representative K(+)-competitive acid blocker, at 7 A resolution based on electron crystallography of two-dimensional crystals. The density of the bound SCH28080 is found near transmembrane (TM) helices 4, 5 and 6, in the luminal cavity. The SCH28080-binding site is formed by the rearrangement of TM helices, which is in turn transmitted to the cytoplasmic domains, resulting in a luminal-open conformation. These results represent the first structural evidence for a binding site of an acid suppressant on H(+),K(+)-ATPase, and the conformational change induced by this class of drugs. | ||
| - | + | Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant.,Abe K, Tani K, Fujiyoshi Y Nat Commun. 2011 Jan;2(1):155. PMID:21224846<ref>PMID:21224846</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2xzb" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| + | *[[ATPase 3D structures|ATPase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Abe K]] | ||
| + | [[Category: Fujiyoshi Y]] | ||
| + | [[Category: Tani K]] | ||
Current revision
Pig Gastric H,K-ATPase with bound BeF and SCH28080
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