2xkv
From Proteopedia
(Difference between revisions)
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:2xkv.jpg|left|200px]] | ||
| - | + | ==Atomic Model of the SRP-FtsY Early Conformation== | |
| - | + | <SX load='2xkv' size='340' side='right' viewer='molstar' caption='[[2xkv]], [[Resolution|resolution]] 13.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2xkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.5Å</td></tr> | |
| - | - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkv OCA], [https://pdbe.org/2xkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkv RCSB], [https://www.ebi.ac.uk/pdbsum/2xkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkv ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SRP54_THEAQ SRP54_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM. FtsY binds to the tetraloop of the SRP RNA, whereas the NG domains of the SRP protein and FtsY interact weakly in this conformation. Our results suggest that optimal positioning of the SRP RNA tetraloop and the Ffh NG domain leads to FtsY recruitment. | ||
| - | + | Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.,Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C Nat Struct Mol Biol. 2011 Jan;18(1):88-90. Epub 2010 Dec 12. PMID:21151118<ref>PMID:21151118</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2xkv" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]] | |
| + | *[[Signal recognition particle receptor 3D structures|Signal recognition particle receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ban | + | [[Category: Ban N]] |
| - | [[Category: Boehringer | + | [[Category: Boehringer D]] |
| - | [[Category: Estrozi | + | [[Category: Estrozi LF]] |
| - | [[Category: Schaffitzel | + | [[Category: Schaffitzel C]] |
| - | [[Category: Shan | + | [[Category: Shan S-o]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Atomic Model of the SRP-FtsY Early Conformation
| |||||||||
