2ptt

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(New page: 200px<br /><applet load="2ptt" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ptt, resolution 1.63&Aring;" /> '''Structure of NK cell...)
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[[Image:2ptt.jpg|left|200px]]<br /><applet load="2ptt" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ptt, resolution 1.63&Aring;" />
 
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'''Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48'''<br />
 
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==Overview==
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==Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48==
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Natural killer (NK) cells eliminate virally infected and tumor cells., Among the receptors regulating NK cell function is 2B4 (CD244), a member, of the signaling lymphocyte-activation molecule (SLAM) family that binds, CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose, other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We, determined the structure of the complex between the N-terminal domains of, mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The, complex displayed an association mode related to, yet distinct from, that, of the NTB-A dimer. Binding was accompanied by the rigidification of, flexible 2B4 regions containing most of the polymorphic residues across, different species and receptor isoforms. We propose a model for 2B4-CD48, interactions that permits the intermixing of SLAM receptors with major, histocompatibility complex-specific receptors in the NK cell immune, synapse. This analysis revealed the basis for heterophilic recognition, within the SLAM family.
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<StructureSection load='2ptt' size='340' side='right'caption='[[2ptt]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ptt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PTT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ptt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ptt OCA], [https://pdbe.org/2ptt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ptt RCSB], [https://www.ebi.ac.uk/pdbsum/2ptt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ptt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD48_MOUSE CD48_MOUSE] Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2ptt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ptt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We determined the structure of the complex between the N-terminal domains of mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The complex displayed an association mode related to, yet distinct from, that of the NTB-A dimer. Binding was accompanied by the rigidification of flexible 2B4 regions containing most of the polymorphic residues across different species and receptor isoforms. We propose a model for 2B4-CD48 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-specific receptors in the NK cell immune synapse. This analysis revealed the basis for heterophilic recognition within the SLAM family.
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==About this Structure==
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.,Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:17950006<ref>PMID:17950006</ref>
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2PTT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTT OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family., Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA, Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17950006 17950006]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 2ptt" style="background-color:#fffaf0;"></div>
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[[Category: Protein complex]]
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[[Category: Deng, L.]]
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[[Category: Mariuzza, R.A.]]
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[[Category: Velikovsky, C.A.]]
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[[Category: SO4]]
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[[Category: 2b4]]
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[[Category: cd244]]
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[[Category: cd48]]
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[[Category: immune system]]
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[[Category: nk cell receptor]]
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[[Category: x-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:09:34 2008''
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==See Also==
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*[[NK cell receptor|NK cell receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Deng L]]
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[[Category: Mariuzza RA]]
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[[Category: Velikovsky CA]]

Current revision

Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48

PDB ID 2ptt

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