3arn

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{{Seed}}
 
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[[Image:3arn.jpg|left|200px]]
 
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==Human dUTPase in complex with novel uracil derivative==
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The line below this paragraph, containing "STRUCTURE_3arn", creates the "Structure Box" on the page.
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<StructureSection load='3arn' size='340' side='right'caption='[[3arn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3arn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSJ:N-{5-[(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHOXY]-2-METHYLPENTAN-2-YL}BENZENESULFONAMIDE'>MSJ</scene></td></tr>
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{{STRUCTURE_3arn| PDB=3arn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3arn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3arn OCA], [https://pdbe.org/3arn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3arn RCSB], [https://www.ebi.ac.uk/pdbsum/3arn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3arn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>
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===Human dUTPase in complex with novel uracil derivative===
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==See Also==
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3ARN is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARN OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: DUTP diphosphatase]]
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[[Category: Large Structures]]
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[[Category: Chong, K T.]]
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[[Category: Chong KT]]
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[[Category: Fukuoka, M.]]
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[[Category: Fukuoka M]]
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[[Category: Miyahara, S.]]
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[[Category: Miyahara S]]
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[[Category: Miyakoshi, H.]]
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[[Category: Miyakoshi H]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:40:05 2010''
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Current revision

Human dUTPase in complex with novel uracil derivative

PDB ID 3arn

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