2ptu

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(New page: 200px<br /><applet load="2ptu" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ptu, resolution 2.38&Aring;" /> '''Structure of NK cell...)
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[[Image:2ptu.jpg|left|200px]]<br /><applet load="2ptu" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ptu, resolution 2.38&Aring;" />
 
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'''Structure of NK cell receptor 2B4 (CD244)'''<br />
 
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==Overview==
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==Structure of NK cell receptor 2B4 (CD244)==
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Natural killer (NK) cells eliminate virally infected and tumor cells., Among the receptors regulating NK cell function is 2B4 (CD244), a member, of the signaling lymphocyte-activation molecule (SLAM) family that binds, CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose, other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We, determined the structure of the complex between the N-terminal domains of, mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The, complex displayed an association mode related to, yet distinct from, that, of the NTB-A dimer. Binding was accompanied by the rigidification of, flexible 2B4 regions containing most of the polymorphic residues across, different species and receptor isoforms. We propose a model for 2B4-CD48, interactions that permits the intermixing of SLAM receptors with major, histocompatibility complex-specific receptors in the NK cell immune, synapse. This analysis revealed the basis for heterophilic recognition, within the SLAM family.
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<StructureSection load='2ptu' size='340' side='right'caption='[[2ptu]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ptu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PTU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ptu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ptu OCA], [https://pdbe.org/2ptu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ptu RCSB], [https://www.ebi.ac.uk/pdbsum/2ptu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ptu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD244_MOUSE CD244_MOUSE] Modulate other receptor-ligand interactions to enhance leukocyte activation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2ptu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ptu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We determined the structure of the complex between the N-terminal domains of mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The complex displayed an association mode related to, yet distinct from, that of the NTB-A dimer. Binding was accompanied by the rigidification of flexible 2B4 regions containing most of the polymorphic residues across different species and receptor isoforms. We propose a model for 2B4-CD48 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-specific receptors in the NK cell immune synapse. This analysis revealed the basis for heterophilic recognition within the SLAM family.
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==About this Structure==
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.,Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:17950006<ref>PMID:17950006</ref>
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2PTU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family., Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA, Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17950006 17950006]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 2ptu" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Deng, L.]]
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[[Category: Mariuzza, R.A.]]
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[[Category: Velikovsky, C.A.]]
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[[Category: 2b4]]
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[[Category: cd244]]
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[[Category: immune system]]
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[[Category: nk cell receptor]]
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[[Category: x-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:09:37 2008''
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==See Also==
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*[[NK cell receptor|NK cell receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Deng L]]
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[[Category: Mariuzza RA]]
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[[Category: Velikovsky CA]]

Current revision

Structure of NK cell receptor 2B4 (CD244)

PDB ID 2ptu

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