3kz7

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[[Image:3kz7.jpg|left|200px]]
 
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==C-terminal domain of Murine FKBP25 rapamycin complex==
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The line below this paragraph, containing "STRUCTURE_3kz7", creates the "Structure Box" on the page.
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<StructureSection load='3kz7' size='340' side='right'caption='[[3kz7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
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{{STRUCTURE_3kz7| PDB=3kz7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz7 OCA], [https://pdbe.org/3kz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kz7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP3_MOUSE FKBP3_MOUSE] FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FKBP25 is a member of the super-family of peptidylprolyl cis/trans isomerases, which is a high affinity binder for the immunosuppressive antibiotic rapamycin (Rpm). FKBP25 isolated from natural sources, its recombinant murine homologue (mFKBP25) and their complexes with rapamycin bind to diverse DNAs, RNAs and heparin affinity beads. The recombinant mFKBP25/rapamycin complex binds to several proteins including the calcineurin-A/calcineurin-B/calmodulin complex and to elongation factor 1beta. We solved the X-ray structure of the C-terminal domain of mFKBP25 bound to rapamycin that has a higher resolution than of its human counterpart, and which clearly illustrates that the positively charged 40s loop is an epitope of the FK506-like binding domain (FKBD) for interactions with various biopolymers.
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===C-terminal domain of Murine FKBP25 rapamycin complex===
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Diversified targets of FKBP25 and its complex with rapamycin.,Galat A, Thai R, Stura EA Int J Biol Macromol. 2014 May 29;69C:344-352. doi:, 10.1016/j.ijbiomac.2014.05.060. PMID:24879919<ref>PMID:24879919</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kz7" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3KZ7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ7 OCA].
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Galat A]]
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[[Category: Galat, A.]]
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[[Category: Stura EA]]
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[[Category: Stura, E A.]]
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[[Category: Fkpb ppiase rapamycin]]
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[[Category: Isomerase]]
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[[Category: Isomerase-inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Rotamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:40:22 2010''
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Current revision

C-terminal domain of Murine FKBP25 rapamycin complex

PDB ID 3kz7

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