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2r9h
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2r9h" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r9h, resolution 3.100Å" /> '''Crystal Structure o...) |
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| - | [[Image:2r9h.jpg|left|200px]]<br /><applet load="2r9h" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2r9h, resolution 3.100Å" /> | ||
| - | '''Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab'''<br /> | ||
| - | == | + | ==Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab== |
| - | + | <StructureSection load='2r9h' size='340' side='right'caption='[[2r9h]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2r9h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9H FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">clcA, eriC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9h OCA], [https://pdbe.org/2r9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9h RCSB], [https://www.ebi.ac.uk/pdbsum/2r9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9h ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [[https://www.uniprot.org/uniprot/CLCA_ECOLI CLCA_ECOLI]] Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.<ref>PMID:12384697</ref> <ref>PMID:14985752</ref> <ref>PMID:16341087</ref> <ref>PMID:16905147</ref> <ref>PMID:18678918</ref> |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [[ | + | <jmolCheckbox> |
| - | [[ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9h_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9h ConSurf]. |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus coli migula 1895]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Miller, C]] | ||
| + | [[Category: Nguitragool, W]] | ||
| + | [[Category: Antiporter]] | ||
| + | [[Category: Chloride]] | ||
| + | [[Category: Clc]] | ||
| + | [[Category: Crosslink]] | ||
| + | [[Category: Disulfide]] | ||
| + | [[Category: Exchanger]] | ||
| + | [[Category: Inner membrane]] | ||
| + | [[Category: Ion transport]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Stress response]] | ||
| + | [[Category: Transmembrane]] | ||
| + | [[Category: Transporter]] | ||
Current revision
Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab
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