Catenin

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[[Image:2z6g1.png|left|200px|thumb|Crystal Structure of a Full-Length Zebrafish β-Catenin, [[2z6g]]]]
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<StructureSection load='2z6g' size='350' side='right' scene='41/417478/Cv/3' caption='Zebrafish β-catenin (PDB code [[2z6g]])'>
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{{STRUCTURE_2z6g| PDB=2z6g | SIZE=300| SCENE=Catenin/Cv/1 |right|CAPTION=Zebrafish β-Catenin, [[2z6g]] }}
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== Function ==
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]]. α-CTN links cadherin (CDH) and α-actinin, it is encoded by 3 genes: α-E-CTN (epithelial), α-T-CTN (membrane bound), and α-N-CTN (neuronal). β-CTN is a subunit of the cadherin complex. It contains armadillo repeats which are a pair of helices forming hairpin structure. γ-CTN (or plakoglobin) is a component of desmosomes and contains armadillo repeats. δ-CTN is expressed in the brain and contains 10 armadillo repeats. p120 CTN is another member of the CTN family. The images at the left and at the right correspond to one representative Catenin, ''i.e.'' the crystal structure of full-length zebrafish β-catenin ([[2z6g]]).
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[[Catenin|Catenins]] (CTN) are proteins which make complexes with [[cadherin]].<ref>PMID:17005550</ref><br />
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* '''α-CTN''' links cadherin (CDH) and α-actinin, it is encoded by 3 genes: '''α-E-CTN''' (epithelial), '''α-T-CTN''' (membrane bound), and '''α-N-CTN''' (neuronal).<br />
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* '''β-CTN''' is a subunit of the cadherin complex. It contains [[Armadillo repeats]] which are a pair of helices forming hairpin structure.<br />
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{{TOC limit|limit=2}}
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* '''γ-CTN''' (or '''plakoglobin''') is a component of desmosomes and contains armadillo repeats.<br />
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* '''δ-CTN''' is expressed in the brain and contains 10 armadillo repeats.<br />
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* '''p120 CTN''' is another member of the CTN family.<br />
== 3D Structures of Catenin ==
== 3D Structures of Catenin ==
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[[Catenin 3D structures]]
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</StructureSection>
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=== P120 CTN ===
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== References ==
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<references/>
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[[Category:Topic Page]]
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[[3l6x]], [[3l6y]] – p120 CTN (mutant) +E-CDH – human<br />
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=== α-CTN ===
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[[1l7c]] – mα-CTN C-terminal - mouse<br />
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[[1h6g]] - hα-CTN M domain<br />
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[[1dov]] - mα-CTN dimerization domain<br />
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[[1dow]] - mα-CTN dimerization domain+ mβ-CTN chimera<br />
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=== β-CTN ===
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[[3diw]] – mβ-CTN C-terminal+Tax interaction protein 1 <br />
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[[2z6g]] - β-CTN – zebrafish<br />
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[[2z6h]] - hβ-CTN C-terminal<br />
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[[2gl7]] - hβ-CTN (mutant)+TCF-4+B-cell lymphoma protein<br />
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[[2g57]] - β-CTN fragment – NMR<br />
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[[3bct]], [[2bct]] - mβ-CTN armadillo repeats<br />
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[[1v18]] - mβ-CTN armadillo repeats+apc protein<br />
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[[1t08]] - hβ-CTN armadillo repeats+apc protein+ hβ-CTN interacting protein<br />
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[[1th1]] - hβ-CTN armadillo repeats+apc protein<br />
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[[1qz7]] - hβ-CTN armadillo repeats+axis inhibition protein <br />
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[[1g3j]] - hβ-CTN armadillo repeats+TCF3-CBD<br />
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[[1p22]] - hβ-CTN +skp1+trcp1<br />
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[[1luj]] - hβ-CTN C-terminal+ hβ-CTN interacting protein<br />
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[[1jdh]], [[1jpw]] - hβ-CTN C-terminal+HTCF-4<br />
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[[1m1e]] - mβ-CTN armadillo repeats + mβ-CTN interacting protein<br />
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[[1jpp]] - mβ-CTN armadillo repeats+apc protein<br />
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[[1i7x]], [[1i7w]] - mβ-CTN armadillo repeats+E-CDH<br />
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[[3ouw]], [[3oux]] - mβ-CTN+lymphoid enhancer-binding factor 1
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=== γ-CTN ===
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[[3ifq]] – hγ-CTN+E-CDH EC1+EC2+EC3<br />
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Current revision

Zebrafish β-catenin (PDB code 2z6g)

Drag the structure with the mouse to rotate

References

  1. ↑ Weis WI, Nelson WJ. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006 Nov 24;281(47):35593-7. Epub 2006 Sep 27. PMID:17005550 doi:http://dx.doi.org/10.1074/jbc.R600027200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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