Fibrinogen

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[[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]]
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<StructureSection load='1n73' size='350' side='right' scene='41/410324/Cv/1' caption='Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code [[1n73]]) '>
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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' />
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== Function ==
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'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>
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'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>
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{{TOC limit|limit=2}}
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==3D Printed Physical Model of Fibrinogen==
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<br clear="all" />
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==3D Structure of Fibrinogen==
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Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
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Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).
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[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
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===Fibrinogen alpha+beta+gamma chains===
 
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==== Human ====
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====The MSOE Center for BioMolecular Modeling====
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hFba + hFbb + hFbg:
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[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]]
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<br />
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hFba + hFbb + hFbg + knobs A & B:
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[[3ghg]], [[2q9i]], [[2z4e]]
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<br />
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hFba + hFbb + hFbg + peptide ligand:
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[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]]
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<br />
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hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor:
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[[2a45]]
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==== Cow ====
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cFba + cFbb + cFbg:
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[[1jy3]], [[1deq]]
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cFba+cFbb+cFbg proteolytic fragment: [[1jy2]]
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==== Sea lamprey ====
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Fba + Fbb + Fbg + peptide ligand:
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[[1n73]], [[1lwu]]
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==== Hen ====
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heFba + heFbb + heFbg:
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[[1ei3]]
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<br />
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heFba + heFbb + heFbg + peptide ligand:
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[[1m1j]]
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===Fibrinogen alpha chain===
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[[Image:CbmUniversityLogo.jpg | left | 150px]]
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cFba: [[2baf]]<br />
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The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery].
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cFba – NMR: [[2jor]]<br />
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hFba EC domain: [[1fzd]] <br />
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===Fibrinogen beta chain===
 
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hFb fragment D: [[1fze]], [[1fza]], [[1fzb]]<br />
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== Structural insights ==
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hFb fragment double-D + peptide ligand: [[1fzf]], [[1fzg]]<br />
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===Fibrinogen gamma chain===
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Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).
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</StructureSection>
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hFbg: [[1fic]], [[1fid]] <br />
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==3D Structure of Fibrinogen==
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hFbg + Ca: [[1fib]]<br />
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hFbg + peptide ligand: [[2fib]], [[3fib]] <br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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hFbg + SaClumping Factor A – ''Staphylococcus aureus'': [[2vr3]]<br />
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{{#tree:id=OrganizedByTopic|openlevels=0|
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hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] <br />
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*Fibrinogen α+β+γ chains
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**[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
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**[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
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**[[2xnx]], [[2xny]] - hFba+hFbb+hFbg + M1 protein<br />
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**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
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**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
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**[[1jy3]], [[1deq]] – bFba+Fbb+Fbg – bovine<br />
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**[[1jy2]] - bFba+Fbb+Fbg proteolytic fragment<br />
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**[[1m1j]] - cFba+Fbb+Fbg+peptide ligand – chicken<br />
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**[[1ei3]] - cFba+Fbb+Fbg<br />
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**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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*Fibrinogen α chain
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**[[1fzd]] – hFba EC domain<br />
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**[[1bbr]] – hFba+cε-thrombin<br />
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**[[2jor]] – bFba – NMR<br />
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**[[2baf]] – bFba<br />
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*Fibrinogen β chain
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**[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
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**[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
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*Fibrinogen γ chain
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**[[1fic]], [[1fid]] – hFbg<br />
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**[[3fib]] – hFbg C terminal<br />
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**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
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**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody <br />
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**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
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**[[1fib]] – hFbg+Ca<br />
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**[[2hwl]] – hFbg peptide+prothrombin<br />
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**[[2y7l]] – hFbg + agglutinin-like protein <br />
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**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
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}}
==References==
==References==
<references />
<references />
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[[Category:Topic Page]]

Current revision

Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73)

Drag the structure with the mouse to rotate

3D Structure of Fibrinogen

Updated on 28-July-2020

References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez

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