3l2c

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{{Seed}}
 
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[[Image:3l2c.png|left|200px]]
 
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==Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA==
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The line below this paragraph, containing "STRUCTURE_3l2c", creates the "Structure Box" on the page.
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<StructureSection load='3l2c' size='340' side='right'caption='[[3l2c]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l2c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bpy 3bpy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L2C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.868&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3l2c| PDB=3l2c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2c OCA], [https://pdbe.org/3l2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l2c RCSB], [https://www.ebi.ac.uk/pdbsum/3l2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l2c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.
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== Function ==
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[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.<ref>PMID:10217147</ref> <ref>PMID:10783894</ref> <ref>PMID:12761217</ref> <ref>PMID:15126506</ref> <ref>PMID:16054032</ref> <ref>PMID:16964248</ref> <ref>PMID:20874444</ref> <ref>PMID:22972301</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/3l2c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l2c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FOXO4 is a member of the FOXO subgroup of forkhead transcription factors that constitute key components of a conserved signalling pathway that connects growth and stress signals to transcriptional control. Here, the 1.9 A resolution crystal structure of the DNA-binding domain of human FOXO4 (FOXO4-DBD) bound to a 13 bp DNA duplex containing a FOXO consensus binding sequence is reported. The structure shows a similar recognition of the core sequence as has been shown for two other FOXO proteins. Helix H3 is docked into the major groove and provides all of the base-specific contacts, while the N-terminus and wing W1 make additional contacts with the phosphate groups of DNA. In contrast to other FOXO-DBD-DNA structures, the loop between helices H2 and H3 has a different conformation and participates in DNA binding. In addition, the structure of the FOXO4-DBD-DNA complex suggests that both direct water-DNA base contacts and the unique water-network interactions contribute to FOXO-DBD binding to the DNA in a sequence-specific manner.
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===Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA===
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Structure of the human FOXO4-DBD-DNA complex at 1.9 A resolution reveals new details of FOXO binding to the DNA.,Boura E, Rezabkova L, Brynda J, Obsilova V, Obsil T Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1351-7. Epub 2010, Nov 16. PMID:21123876<ref>PMID:21123876</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3l2c" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21123876}}, adds the Publication Abstract to the page
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*[[FOX 3D structures|FOX 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21123876 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21123876}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3L2C is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bpy 3bpy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2C OCA].
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==Reference==
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<ref group="xtra">PMID:21123876</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boura, E.]]
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[[Category: Large Structures]]
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[[Category: Brynda, J.]]
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[[Category: Boura E]]
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[[Category: Obsil, T.]]
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[[Category: Brynda J]]
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[[Category: Obsilova, V.]]
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[[Category: Obsil T]]
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[[Category: Silhan, J.]]
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[[Category: Obsilova V]]
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[[Category: Sulc, M.]]
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[[Category: Silhan J]]
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[[Category: Forkhead]]
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[[Category: Sulc M]]
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[[Category: Forkhead box]]
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[[Category: Transcription-dna complex]]
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[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:03:15 2010''
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Current revision

Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA

PDB ID 3l2c

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