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3p77

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{{Seed}}
 
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[[Image:3p77.png|left|200px]]
 
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==Crystal Structures of the Chicken YF1*7.1 molecule==
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<StructureSection load='3p77' size='340' side='right'caption='[[3p77]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P77 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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{{STRUCTURE_3p77| PDB=3p77 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p77 OCA], [https://pdbe.org/3p77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p77 RCSB], [https://www.ebi.ac.uk/pdbsum/3p77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p77 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9BCW3_CHICK Q9BCW3_CHICK]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/beta(2)-microgloblin complex by X-ray crystallography at 1.3 A resolution. It exhibits the architecture typical of classical MHC class I molecules but possesses a hydrophobic binding groove that contains a non-peptidic ligand. This finding prompted us to reconstitute YF1*7.1 also with various self-lipids. Seven additional YF1*7.1 structures were solved, but only polyethyleneglycol molecules could be modeled into the electron density within the binding groove. However, an assessment of YF1*7.1 by native isoelectric focusing indicated that the molecules were also able to bind nonself-lipids. The ability of YF1*7.1 to interact with hydrophobic ligands is unprecedented among classical MHC class I proteins and might aid the chicken immune system to recognize a diverse ligand repertoire with a minimal number of MHC class I molecules.
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===Crystal Structures of the Chicken YF1*7.1 molecule===
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Structure of a classical MHC class I molecule that binds "non-classical" ligands.,Hee CS, Gao S, Loll B, Miller MM, Uchanska-Ziegler B, Daumke O, Ziegler A PLoS Biol. 2010 Dec 7;8(12):e1000557. PMID:21151886<ref>PMID:21151886</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3p77" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21151886 is the PubMed ID number.
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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{{ABSTRACT_PUBMED_21151886}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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3P77 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P77 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:21151886</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Daumke, O.]]
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[[Category: Large Structures]]
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[[Category: Gao, S.]]
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[[Category: Daumke O]]
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[[Category: Hee, C S.]]
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[[Category: Gao S]]
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[[Category: Loll, B.]]
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[[Category: Hee CS]]
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[[Category: Miller, M M.]]
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[[Category: Loll B]]
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[[Category: Uchanska-Ziegler, B.]]
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[[Category: Miller MM]]
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[[Category: Ziegler, A.]]
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[[Category: Uchanska-Ziegler B]]
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[[Category: Histocompatibility antigen]]
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[[Category: Ziegler A]]
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[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:06:42 2010''
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Current revision

Crystal Structures of the Chicken YF1*7.1 molecule

PDB ID 3p77

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