2l0r

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{{Seed}}
 
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[[Image:2l0r.jpg|left|200px]]
 
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==Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center==
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The line below this paragraph, containing "STRUCTURE_2l0r", creates the "Structure Box" on the page.
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<StructureSection load='2l0r' size='340' side='right'caption='[[2l0r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0r OCA], [https://pdbe.org/2l0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0r RCSB], [https://www.ebi.ac.uk/pdbsum/2l0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0r ProSAT]</span></td></tr>
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{{STRUCTURE_2l0r| PDB=2l0r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEF_BACAN LEF_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.<ref>PMID:9563949</ref> <ref>PMID:9703991</ref> <ref>PMID:10475971</ref> <ref>PMID:11104681</ref> <ref>PMID:10338520</ref>
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===Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center===
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==See Also==
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*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21121613 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21121613}}
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==About this Structure==
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2L0R is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0R OCA].
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==Reference==
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<ref group="xtra">PMID:21121613</ref><references group="xtra"/>
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[[Category: Anthrax lethal factor endopeptidase]]
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Bentrop, D A.]]
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[[Category: Large Structures]]
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[[Category: Chasapis, C T.]]
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[[Category: Bentrop DA]]
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[[Category: Dalkas, G A.]]
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[[Category: Chasapis CT]]
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[[Category: Gkazonis, P V.]]
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[[Category: Dalkas GA]]
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[[Category: Spyroulias, G A.]]
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[[Category: Gkazonis PV]]
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[[Category: Anthrax lethal factor]]
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[[Category: Spyroulias GA]]
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[[Category: Bacillus anthracis]]
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[[Category: Catalytic domain]]
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[[Category: Hydrolase]]
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[[Category: Protein]]
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[[Category: Toxin]]
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[[Category: Zn metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:49:40 2010''
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Current revision

Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center

PDB ID 2l0r

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