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3lca

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{{Seed}}
 
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[[Image:3lca.jpg|left|200px]]
 
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==Structure of Tom71 complexed with Hsp70 Ssa1 C terminal tail indicating conformational plasticity==
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The line below this paragraph, containing "STRUCTURE_3lca", creates the "Structure Box" on the page.
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<StructureSection load='3lca' size='340' side='right'caption='[[3lca]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lca]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LCA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3lca| PDB=3lca | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lca OCA], [https://pdbe.org/3lca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lca RCSB], [https://www.ebi.ac.uk/pdbsum/3lca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lca ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOM71_YEAST TOM71_YEAST] Involved in MBF1-mediated mitochondrial morphogenesis.<ref>PMID:18007655</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mitochondrial precursors are transported through the translocase of the outer membrane (TOM) complex. Tom70/Tom71 is a major surface receptor of the TOM complex for mitochondrial precursors and facilitates Hsp70/Hsp90-escorted precursor translocation into the mitochondrion. Previous structural studies of Tom71 have revealed that it contains an N-terminal and a C-terminal domain and that the two domains may remain in an open conformation when binding to Hsp70/Hsp90. In a newly obtained crystal form of a complex of Tom71 and the Hsp70 C-terminus, the N-terminal domain was found to have rotated about 12 degrees towards the C-terminal domain compared with the previous determined crystal structure of Tom71 in the open conformation. This newly solved structure is defined as the ;intermediate conformation'. The domain rearrangements in Tom71 significantly change the surface hydrophobicity and the volume of the precursor-binding pocket. This work suggests that Tom70/Tom71-family members may exhibit structural plasticity from the intermediate conformation to the fully open conformation when complexed with Hsp70/Hsp90. This structural plasticity enables the precursor receptors to accommodate different precursor substrates for mitochondrial translocation.
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===Structure of Tom71 complexed with Hsp70 Ssa1 C terminal tail indicating conformational plasticity===
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The structural plasticity of Tom71 for mitochondrial precursor translocations.,Li J, Cui W, Sha B Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):985-9. Epub 2010 Aug 21. PMID:20823510<ref>PMID:20823510</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3lca" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20823510 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20823510}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3LCA is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCA OCA].
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==Reference==
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<ref group="xtra">PMID:20823510</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Li, J Z.]]
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[[Category: Li JZ]]
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[[Category: Sha, B D]]
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[[Category: Sha BD]]
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[[Category: Chaperone]]
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[[Category: Conformational plasticity]]
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[[Category: Membrane]]
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[[Category: Mitochondrion]]
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[[Category: Mitochondrion outer membrane]]
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[[Category: Tpr repeat]]
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[[Category: Transmembrane]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:53:13 2010''
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Current revision

Structure of Tom71 complexed with Hsp70 Ssa1 C terminal tail indicating conformational plasticity

PDB ID 3lca

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