3px3

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{{Seed}}
 
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[[Image:3px3.jpg|left|200px]]
 
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==Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N==
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The line below this paragraph, containing "STRUCTURE_3px3", creates the "Structure Box" on the page.
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<StructureSection load='3px3' size='340' side='right'caption='[[3px3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3px3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PX3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T3Q:[(3R,4S,5S,6R)-4-AMINO-3,5-DIHYDROXY-6-METHYLOXAN-2-YL][HYDROXY-[[(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXOPYRIMIDIN-1-YL)OXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>T3Q</scene></td></tr>
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{{STRUCTURE_3px3| PDB=3px3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3px3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3px3 OCA], [https://pdbe.org/3px3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3px3 RCSB], [https://www.ebi.ac.uk/pdbsum/3px3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3px3 ProSAT]</span></td></tr>
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</table>
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===Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N===
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== Function ==
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[https://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>
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== References ==
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==About this Structure==
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<references/>
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3PX3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX3 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces fradiae]]
[[Category: Streptomyces fradiae]]
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[[Category: Carney, A E.]]
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[[Category: Carney AE]]
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[[Category: Holden, H M.]]
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[[Category: Holden HM]]
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[[Category: Dtdp-quip3n binding]]
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[[Category: N-dimethyltransferase]]
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[[Category: Sam binding]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 10:03:17 2010''
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Current revision

Structure of TylM1 from Streptomyces fradiae H123A mutant in complex with SAH and dTDP-Quip3N

PDB ID 3px3

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