2eh0

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[[Image:2eh0.png|left|200px]]
 
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==Solution structure of the FHA domain from human Kinesin-like protein KIF1B==
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The line below this paragraph, containing "STRUCTURE_2eh0", creates the "Structure Box" on the page.
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<StructureSection load='2eh0' size='340' side='right'caption='[[2eh0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2eh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EH0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eh0 OCA], [https://pdbe.org/2eh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eh0 RCSB], [https://www.ebi.ac.uk/pdbsum/2eh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eh0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eh0 TOPSAN]</span></td></tr>
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{{STRUCTURE_2eh0| PDB=2eh0 | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the FHA domain from human Kinesin-like protein KIF1B===
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[https://www.uniprot.org/uniprot/KIF1B_HUMAN KIF1B_HUMAN] Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM:[https://omim.org/entry/118210 118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.<ref>PMID:11389829</ref> Defects in KIF1B are the cause of susceptibility to neuroblastoma type 1 (NBLST1) [MIM:[https://omim.org/entry/256700 256700]. A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. Defects in KIF1B are a cause of susceptibility to pheochromocytoma (PCC) [MIM:[https://omim.org/entry/171300 171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
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== Function ==
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[https://www.uniprot.org/uniprot/KIF1B_HUMAN KIF1B_HUMAN] Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.<ref>PMID:18334619</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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[[2eh0]] is a 1 chain structure of [[Kinesin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EH0 OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2eh0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eh0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Kinesin]]
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Inoue, K.]]
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[[Category: Hayashi F]]
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[[Category: Nagashima, T.]]
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[[Category: Inoue K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nagashima T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Fha domain]]
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[[Category: Kiaa0591]]
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[[Category: Kiaa1448]]
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[[Category: Kif1b]]
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[[Category: Kinesin-like protein kif1b]]
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[[Category: Klp]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transport protein]]
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Current revision

Solution structure of the FHA domain from human Kinesin-like protein KIF1B

PDB ID 2eh0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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