3fyq

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[[Image:3fyq.png|left|200px]]
 
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==Structure of Drosophila melanogaster talin IBS2 domain (residues 1981-2168)==
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The line below this paragraph, containing "STRUCTURE_3fyq", creates the "Structure Box" on the page.
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<StructureSection load='3fyq' size='340' side='right'caption='[[3fyq]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FYQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3fyq| PDB=3fyq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fyq OCA], [https://pdbe.org/3fyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fyq RCSB], [https://www.ebi.ac.uk/pdbsum/3fyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fyq ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/3fyq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fyq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Integrins are transmembrane receptors that mediate cell adhesion to the extracellular matrix and play essential roles in tissue development and maintenance. The cytoplasmic segment of integrin associates with talin, a large intracellular protein that links integrin to the actin cytoskeleton. Binding of talin via an integrin binding segment (IBS1) results in large conformational changes in the extracellular portion of integrin, which modulates the affinity of integrins for their extracellular matrix ligands. However, integrin binding also requires a second segment of talin (IBS2). Despite detailed descriptions of the integrin-IBS1 binding, the molecular determinants that drive the integrin-IBS2 association are poorly understood. Here, we describe the crystal structure of the talin IBS2 domain, which forms a five-helix bundle. The large structural homology with a vinculin binding domain hints at an ancient gene duplication and suggests that helix 4 may bind to vinculin if the bundle is unfolded. Mapping previous mutations on the surface highlights a likely binding interface for integrin.
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===Structure of Drosophila melanogaster talin IBS2 domain (residues 1981-2168)===
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Crystal structure of the talin integrin binding domain 2.,Cheung TY, Fairchild MJ, Zarivach R, Tanentzapf G, Van Petegem F J Mol Biol. 2009 Apr 10;387(4):787-93. PMID:19340939<ref>PMID:19340939</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19340939}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3fyq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19340939 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19340939}}
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==About this Structure==
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[[3fyq]] is a 1 chain structure of [[Talin]] with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYQ OCA].
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==See Also==
==See Also==
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*[[Talin]]
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*[[Talin 3D structures|Talin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19340939</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Cheung, T Y.S]]
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[[Category: Large Structures]]
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[[Category: Fairchild, M J.]]
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[[Category: Cheung TYS]]
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[[Category: Petegem, F Van.]]
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[[Category: Fairchild MJ]]
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[[Category: Tanentzapf, G.]]
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[[Category: Tanentzapf G]]
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[[Category: Zarivach, R.]]
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[[Category: Van Petegem F]]
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[[Category: 5-helix bundle]]
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[[Category: Zarivach R]]
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[[Category: Cell adhesion]]
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Current revision

Structure of Drosophila melanogaster talin IBS2 domain (residues 1981-2168)

PDB ID 3fyq

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