3eps

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3eps" [edit=sysop:move=sysop])
Current revision (09:49, 21 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3eps.png|left|200px]]
 
-
<!--
+
==The crystal structure of isocitrate dehydrogenase kinase/phosphatase from E. coli==
-
The line below this paragraph, containing "STRUCTURE_3eps", creates the "Structure Box" on the page.
+
<StructureSection load='3eps' size='340' side='right'caption='[[3eps]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3eps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPS FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_3eps| PDB=3eps | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eps OCA], [https://pdbe.org/3eps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eps RCSB], [https://www.ebi.ac.uk/pdbsum/3eps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eps ProSAT], [https://www.topsan.org/Proteins/BSGI/3eps TOPSAN]</span></td></tr>
-
 
+
</table>
-
===The crystal structure of isocitrate dehydrogenase kinase/phosphatase from E. coli===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/ACEK_ECO57 ACEK_ECO57] Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_20505668}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20505668 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3eps_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_20505668}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[3eps]] is a 2 chain structure of [[Isocitrate dehydrogenase kinase/phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPS OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eps ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Isocitrate dehydrogenase kinase/phosphatase]]
+
*[[Isocitrate dehydrogenase kinase/phosphatase|Isocitrate dehydrogenase kinase/phosphatase]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:20505668</ref><references group="xtra"/>
+
[[Category: Escherichia coli O157:H7]]
-
[[Category: Escherichia coli o157:h7]]
+
[[Category: Large Structures]]
-
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
+
[[Category: Jia Z]]
-
[[Category: Jia, Z.]]
+
[[Category: Zheng J]]
-
[[Category: Zheng, J.]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Bsgi]]
+
-
[[Category: Glyoxylate bypass]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Kinase]]
+
-
[[Category: Kinase phosphatase]]
+
-
[[Category: Montreal-kingston bacterial structural genomics initiative]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Protein phosphatase]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transferase]]
+
-
[[Category: Tricarboxylic acid cycle]]
+

Current revision

The crystal structure of isocitrate dehydrogenase kinase/phosphatase from E. coli

PDB ID 3eps

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3eps"
Personal tools