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3d0b

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[[Image:3d0b.png|left|200px]]
 
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==Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90==
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The line below this paragraph, containing "STRUCTURE_3d0b", creates the "Structure Box" on the page.
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<StructureSection load='3d0b' size='340' side='right'caption='[[3d0b]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D0B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SNX:2-[(2-METHOXYETHYL)AMINO]-4-(4-OXO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)BENZAMIDE'>SNX</scene></td></tr>
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{{STRUCTURE_3d0b| PDB=3d0b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d0b OCA], [https://pdbe.org/3d0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d0b RCSB], [https://www.ebi.ac.uk/pdbsum/3d0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d0b ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90===
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18511277 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/3d0b_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18511277}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3d0b]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0B OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d0b ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18511277</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barta, T E.]]
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[[Category: Large Structures]]
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[[Category: Hall, S H.]]
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[[Category: Barta TE]]
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[[Category: Huang, K H.]]
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[[Category: Hall SH]]
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[[Category: Veal, J M.]]
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[[Category: Huang KH]]
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[[Category: Alternative splicing]]
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[[Category: Veal JM]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Cytoplasm]]
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[[Category: Heat shock protein 90]]
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[[Category: Hsp90]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Stress response]]
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Current revision

Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90

PDB ID 3d0b

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