2oit

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[[Image:2oit.png|left|200px]]
 
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==Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN==
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The line below this paragraph, containing "STRUCTURE_2oit", creates the "Structure Box" on the page.
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<StructureSection load='2oit' size='340' side='right'caption='[[2oit]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2oit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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{{STRUCTURE_2oit| PDB=2oit | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oit OCA], [https://pdbe.org/2oit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oit RCSB], [https://www.ebi.ac.uk/pdbsum/2oit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oit ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
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== Function ==
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[https://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oit_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oit ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mammalian nuclear pore complex (NPC) is an approximately 120-MDa proteinaceous assembly consisting of approximately 30 proteins and is the sole gate in the nuclear envelope. The human protooncogene Nup214 was first identified as a target for chromosomal translocation involved in leukemogenesis. Nup214 is located on the cytoplasmic face of the NPC and is implicated in anchoring the cytoplasmic filaments of the NPC and recruiting the RNA helicase Ddx19. Here, we present the crystal structure of the human Nup214 N-terminal domain at 1.65-A resolution. The structure reveals a seven-bladed beta-propeller followed by a 30-residue C-terminal extended peptide segment, which folds back onto the beta-propeller and binds to its bottom face. The beta-propeller repeats lack any recognizable sequence motif and are distinguished by extensive insertions between the canonical beta-strands. We propose a mechanism by which the C-terminal peptide extension is involved in NPC assembly.
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===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===
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Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.,Napetschnig J, Blobel G, Hoelz A Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208<ref>PMID:17264208</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2oit" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17264208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17264208}}
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==About this Structure==
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[[2oit]] is a 1 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIT OCA].
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==See Also==
==See Also==
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*[[Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17264208</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blobel, G.]]
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[[Category: Large Structures]]
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[[Category: Hoelz, A.]]
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[[Category: Blobel G]]
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[[Category: Napetschnig, J.]]
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[[Category: Hoelz A]]
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[[Category: Beta-propeller]]
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[[Category: Napetschnig J]]
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[[Category: Dbp5/ddx19]]
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[[Category: Leukemia]]
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[[Category: Mrna export]]
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[[Category: Nh2 terminal domain of nup214/can]]
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[[Category: Npc assembly]]
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[[Category: Nup214/can fusion]]
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[[Category: Oncoprotein]]
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[[Category: Structure]]
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[[Category: X-ray crystallography]]
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Current revision

Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN

PDB ID 2oit

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