1snk

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[[Image:1snk.png|left|200px]]
 
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==Cathepsin K complexed with carbamate derivatized norleucine aldehyde==
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The line below this paragraph, containing "STRUCTURE_1snk", creates the "Structure Box" on the page.
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<StructureSection load='1snk' size='340' side='right'caption='[[1snk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1snk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYE:N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE'>MYE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1snk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1snk OCA], [https://pdbe.org/1snk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1snk RCSB], [https://www.ebi.ac.uk/pdbsum/1snk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1snk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1snk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1snk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM.
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===Cathepsin K complexed with carbamate derivatized norleucine aldehyde===
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Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors.,Boros EE, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Paulick MG, Shewchuk LM, Thompson JB, Willard DH Jr, Wright LL Bioorg Med Chem Lett. 2004 Jul 5;14(13):3425-9. PMID:15177446<ref>PMID:15177446</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15177446}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1snk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15177446 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15177446}}
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==About this Structure==
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[[1snk]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNK OCA].
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==See Also==
==See Also==
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*[[Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:15177446</ref><references group="xtra"/>
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__TOC__
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[[Category: Cathepsin K]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boros, E E.]]
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[[Category: Large Structures]]
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[[Category: Deaton, D N.]]
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[[Category: Boros EE]]
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[[Category: Hassell, A M.]]
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[[Category: Deaton DN]]
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[[Category: McFadyen, R B.]]
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[[Category: Hassell AM]]
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[[Category: Miller, A B.]]
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[[Category: McFadyen RB]]
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[[Category: Miller, L R.]]
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[[Category: Miller AB]]
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[[Category: Shewchuk, L M.]]
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[[Category: Miller LR]]
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[[Category: Thompson, J B.]]
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[[Category: Shewchuk LM]]
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[[Category: Willard, D H.]]
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[[Category: Thompson JB]]
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[[Category: Wright, L L.]]
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[[Category: Willard Jr DH]]
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[[Category: Catk]]
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[[Category: Wright LL]]
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[[Category: Hydrolase]]
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Current revision

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

PDB ID 1snk

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