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2r0o

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[[Image:2r0o.png|left|200px]]
 
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==Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)==
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The line below this paragraph, containing "STRUCTURE_2r0o", creates the "Structure Box" on the page.
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<StructureSection load='2r0o' size='340' side='right'caption='[[2r0o]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R0O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2r0o| PDB=2r0o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r0o OCA], [https://pdbe.org/2r0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r0o RCSB], [https://www.ebi.ac.uk/pdbsum/2r0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r0o ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)===
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== Disease ==
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[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:[https://omim.org/entry/603278 603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:10700177</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
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The line below this paragraph, {{ABSTRACT_PUBMED_18164029}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 18164029 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_18164029}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/2r0o_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[2r0o]] is a 2 chain structure of [[Actinin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R0O OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r0o ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Actinin]]
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*[[Actinin 3D structures|Actinin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18164029</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dominguez, R.]]
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[[Category: Large Structures]]
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[[Category: Lee, S H.]]
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[[Category: Dominguez R]]
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[[Category: Actin-binding protein]]
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[[Category: Lee SH]]
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[[Category: Actin-crosslinking]]
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[[Category: Calcium]]
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[[Category: Calponin homology domain]]
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[[Category: Ch domain]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Glomeruloscleros spectrin family]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)

PDB ID 2r0o

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