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2khw

From Proteopedia

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[[Image:2khw.png|left|200px]]
 
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==Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex==
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The line below this paragraph, containing "STRUCTURE_2khw", creates the "Structure Box" on the page.
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<StructureSection load='2khw' size='340' side='right'caption='[[2khw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2khw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khw OCA], [https://pdbe.org/2khw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khw RCSB], [https://www.ebi.ac.uk/pdbsum/2khw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khw ProSAT]</span></td></tr>
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{{STRUCTURE_2khw| PDB=2khw | SCENE= }}
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</table>
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== Function ==
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===Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex===
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[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG] [https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[2khw]] is a 2 chain structure of [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_sp.,_homo_sapiens Streptococcus sp., homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHW OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/2khw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ubiquitin]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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[[Category: DNA-directed DNA polymerase]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Streptococcus sp., homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bienko, M.]]
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[[Category: Streptococcus sp. 'group G']]
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[[Category: Bomar, M G.]]
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[[Category: Bienko M]]
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[[Category: Dikic, I.]]
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[[Category: Bomar MG]]
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[[Category: Souza, S D.]]
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[[Category: D'Souza S]]
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[[Category: Walker, G.]]
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[[Category: Dikic I]]
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[[Category: Cytoplasm]]
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[[Category: Walker G]]
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[[Category: Nucleus]]
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[[Category: Polymerase iota]]
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[[Category: Protein binding]]
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[[Category: Tl]]
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[[Category: Transcription regulator activity]]
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[[Category: Transferase-protein binding complex]]
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[[Category: Translesion synthesis]]
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[[Category: Ubiquitin-binding domain]]
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[[Category: Ubm]]
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Current revision

Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex

PDB ID 2khw

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