3d9s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:05, 1 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3d9s.png|left|200px]]
 
-
<!--
+
==Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure==
-
The line below this paragraph, containing "STRUCTURE_3d9s", creates the "Structure Box" on the page.
+
<StructureSection load='3d9s' size='340' side='right'caption='[[3d9s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3d9s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D9S FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr>
-
{{STRUCTURE_3d9s| PDB=3d9s | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9s OCA], [https://pdbe.org/3d9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d9s RCSB], [https://www.ebi.ac.uk/pdbsum/3d9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d9s ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9s_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d9s ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear. AQP5, like AQP2, is subject to posttranslational regulation by phosphorylation, at which point it is trafficked between intracellular storage compartments and the plasma membrane. Details concerning the molecular mechanism of membrane trafficking are unknown. Here we report the x-ray structure of HsAQP5 to 2.0-A resolution and highlight structural similarities and differences relative to other eukaryotic aquaporins. A lipid occludes the putative central pore, preventing the passage of gas or ions through the center of the tetramer. Multiple consensus phosphorylation sites are observed in the structure and their potential regulatory role is discussed. We postulate that a change in the conformation of the C terminus may arise from the phosphorylation of AQP5 and thereby signal trafficking.
-
===Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure===
+
High-resolution x-ray structure of human aquaporin 5.,Horsefield R, Norden K, Fellert M, Backmark A, Tornroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U, Neutze R Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13327-32. Epub 2008 Sep 3. PMID:18768791<ref>PMID:18768791</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18768791}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3d9s" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18768791 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_18768791}}
+
-
 
+
-
==About this Structure==
+
-
[[3d9s]] is a 4 chain structure of [[Aquaporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9S OCA].
+
==See Also==
==See Also==
-
*[[Aquaporin]]
+
*[[Aquaporin 3D structures|Aquaporin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:18768791</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Backmark, A.]]
+
[[Category: Large Structures]]
-
[[Category: Fellert, M.]]
+
[[Category: Backmark A]]
-
[[Category: Horsefield, R.]]
+
[[Category: Fellert M]]
-
[[Category: Johanson, U.]]
+
[[Category: Horsefield R]]
-
[[Category: Kjellbom, P.]]
+
[[Category: Johanson U]]
-
[[Category: Kvassman, J.]]
+
[[Category: Kjellbom P]]
-
[[Category: Neutze, R.]]
+
[[Category: Kvassman J]]
-
[[Category: Norden, K.]]
+
[[Category: Neutze R]]
-
[[Category: Scheltinga, A C.Terwisscha Van.]]
+
[[Category: Norden K]]
-
[[Category: Tornroth-Horsefield, S.]]
+
[[Category: Terwisscha Van Scheltinga AC]]
-
[[Category: Aqp]]
+
[[Category: Tornroth-Horsefield S]]
-
[[Category: Aquaglyceroporin]]
+
-
[[Category: Aquaporin]]
+
-
[[Category: Ar/r]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Lipid]]
+
-
[[Category: Membrane]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Npa]]
+
-
[[Category: Phosphatidylserine]]
+
-
[[Category: Psf]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Transport]]
+
-
[[Category: Water channel]]
+
-
[[Category: Water transport]]
+
-
[[Category: X-ray diffraction]]
+

Current revision

Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure

PDB ID 3d9s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3d9s"
Personal tools