3i5f

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[[Image:3i5f.png|left|200px]]
 
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==Crystal structure of squid MG.ADP myosin S1==
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The line below this paragraph, containing "STRUCTURE_3i5f", creates the "Structure Box" on the page.
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<StructureSection load='3i5f' size='340' side='right'caption='[[3i5f]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3i5f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii] and [https://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2oy6 2oy6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I5F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3i5f| PDB=3i5f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5f OCA], [https://pdbe.org/3i5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i5f RCSB], [https://www.ebi.ac.uk/pdbsum/3i5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O44934_DORPE O44934_DORPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i5f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Unlike processive cellular motors such as myosin V, whose structure has recently been determined in a "rigor-like" conformation, myosin II from contracting muscle filaments necessarily spends most of its time detached from actin. By using squid and sea scallop sources, however, we have now obtained similar rigor-like atomic structures for muscle myosin heads (S1). The significance of the hallmark closed actin-binding cleft in these crystal structures is supported here by actin/S1-binding studies. These structures reveal how different duty ratios, and hence cellular functions, of the myosin isoforms may be accounted for, in part, on the basis of detailed differences in interdomain contacts. Moreover, the rigor-like position of switch II turns out to be unique for myosin V. The overall arrangements of subdomains in the motor are relatively conserved in each of the known contractile states, and we explore qualitatively the energetics of these states.
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===Crystal structure of squid MG.ADP myosin S1===
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Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.,Yang Y, Gourinath S, Kovacs M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Gyorgyi AG, Brown JH, Cohen C Structure. 2007 May;15(5):553-64. PMID:17502101<ref>PMID:17502101</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17502101}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3i5f" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17502101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502101}}
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==About this Structure==
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[[3i5f]] is a 3 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Loligo_pealei Loligo pealei] and [http://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2oy6 2oy6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5F OCA].
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==See Also==
==See Also==
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*[[Myosin]]
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:17502101</ref><references group="xtra"/>
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<references/>
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[[Category: Loligo pealei]]
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__TOC__
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</StructureSection>
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[[Category: Doryteuthis pealeii]]
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[[Category: Large Structures]]
[[Category: Todarodes pacificus]]
[[Category: Todarodes pacificus]]
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[[Category: Brown, J H.]]
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[[Category: Brown JH]]
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[[Category: Cohen, C.]]
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[[Category: Cohen C]]
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[[Category: Gourinath, S.]]
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[[Category: Gourinath S]]
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[[Category: Himmel, D M.]]
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[[Category: Himmel DM]]
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[[Category: Kovacs, M.]]
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[[Category: Kovacs M]]
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[[Category: Neall-Hennessey, E O.]]
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[[Category: Nyitray L]]
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[[Category: Nyitray, L.]]
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[[Category: O'Neall-Hennessey E]]
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[[Category: Reshetnikova, L.]]
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[[Category: Reshetnikova L]]
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[[Category: Reutzel, R.]]
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[[Category: Reutzel R]]
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[[Category: Szent-Gyorgyi, A G.]]
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[[Category: Szent-Gyorgyi AG]]
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[[Category: Yang, Y.]]
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[[Category: Yang Y]]
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[[Category: Actin-binding]]
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[[Category: Atp-binding]]
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[[Category: Calcium]]
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[[Category: Coiled coil]]
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[[Category: Contractile protein]]
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[[Category: Mg adp]]
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[[Category: Motor protein]]
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[[Category: Muscle protein]]
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[[Category: Myosin]]
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[[Category: Myosin ii s1]]
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[[Category: Nucleotide-binding]]
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[[Category: Post-rigor state]]
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[[Category: Squid]]
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[[Category: Thick filament]]
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Current revision

Crystal structure of squid MG.ADP myosin S1

PDB ID 3i5f

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