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1fid

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[[Image:1fid.png|left|200px]]
 
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==STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT==
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The line below this paragraph, containing "STRUCTURE_1fid", creates the "Structure Box" on the page.
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<StructureSection load='1fid' size='340' side='right'caption='[[1fid]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fid]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FID FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1fid| PDB=1fid | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fid OCA], [https://pdbe.org/1fid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fid RCSB], [https://www.ebi.ac.uk/pdbsum/1fid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fid ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT===
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== Disease ==
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[https://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN] Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:[https://omim.org/entry/202400 202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
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== Function ==
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[https://www.uniprot.org/uniprot/FIBG_HUMAN FIBG_HUMAN] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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The line below this paragraph, {{ABSTRACT_PUBMED_9016719}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 9016719 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_9016719}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/1fid_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[1fid]] is a 1 chain structure of [[Fibrinogen]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FID OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fid ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Fibrinogen]]
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*[[Fibrinogen|Fibrinogen]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:9016719</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Teller, D C.]]
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[[Category: Large Structures]]
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[[Category: Yee, V C.]]
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[[Category: Teller DC]]
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[[Category: Alternative splicing]]
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[[Category: Yee VC]]
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[[Category: Blood coagulation]]
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[[Category: Blood coagulation factor]]
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[[Category: Calcium]]
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[[Category: Disease mutation]]
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[[Category: Glycoprotein]]
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[[Category: Plasma]]
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[[Category: Platelet]]
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[[Category: Polymorphism]]
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[[Category: Signal]]
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Current revision

STRUCTURE OF HUMAN GAMMA FIBRINOGEN 30 KD CARBOXYL TERMINAL FRAGMENT

PDB ID 1fid

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