2jzi

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[[Image:2jzi.png|left|200px]]
 
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==Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin==
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The line below this paragraph, containing "STRUCTURE_2jzi", creates the "Structure Box" on the page.
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<StructureSection load='2jzi' size='340' side='right'caption='[[2jzi]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2jzi| PDB=2jzi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzi OCA], [https://pdbe.org/2jzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzi RCSB], [https://www.ebi.ac.uk/pdbsum/2jzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzi ProSAT]</span></td></tr>
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</table>
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===Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin===
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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[[2jzi]] is a 2 chain structure of [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZI OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jzi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Chyan, C.]]
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[[Category: Chyan C]]
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[[Category: Huang, J.]]
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[[Category: Huang J]]
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[[Category: Irene, D.]]
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[[Category: Irene D]]
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[[Category: Lin, T.]]
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[[Category: Lin T]]
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[[Category: Acetylation]]
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[[Category: Alternative splicing]]
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[[Category: Calcium binding protein]]
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[[Category: Calmodulin-binding]]
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[[Category: Hydrolase]]
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[[Category: Iron]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein phosphatase]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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Current revision

Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin

PDB ID 2jzi

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