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1kij

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[[Image:1kij.png|left|200px]]
 
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==Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin==
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The line below this paragraph, containing "STRUCTURE_1kij", creates the "Structure Box" on the page.
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<StructureSection load='1kij' size='340' side='right'caption='[[1kij]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kij]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KIJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NOV:NOVOBIOCIN'>NOV</scene></td></tr>
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{{STRUCTURE_1kij| PDB=1kij | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kij OCA], [https://pdbe.org/1kij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kij RCSB], [https://www.ebi.ac.uk/pdbsum/1kij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kij ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin===
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_THET8 GYRB_THET8] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:23804759, PubMed:11850422). It probably also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:11850422). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:23804759, PubMed:11850422). At comparable concentrations T.thermophilus gyrase does not introduce as many negative supercoils into DNA as the E.coli enzyme (PubMed:23804759).<ref>PMID:23804759</ref> Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11850422}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11850422 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1kij_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11850422}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1kij]] is a 2 chain structure of [[Gyrase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIJ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kij ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Gyrase]]
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:11850422</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Hoermann, L.]]
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[[Category: Hoermann L]]
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[[Category: Jeltsch, J M.]]
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[[Category: Jeltsch J-M]]
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[[Category: Lamour, V.]]
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[[Category: Lamour V]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Oudet, P.]]
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[[Category: Oudet P]]
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[[Category: Gyrase b-coumarin complex]]
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[[Category: Topoisomerase]]
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Current revision

Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin

PDB ID 1kij

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