2rpq

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[[Image:2rpq.png|left|200px]]
 
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==Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3==
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The line below this paragraph, containing "STRUCTURE_2rpq", creates the "Structure Box" on the page.
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<StructureSection load='2rpq' size='340' side='right'caption='[[2rpq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rpq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RPQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rpq OCA], [https://pdbe.org/2rpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rpq RCSB], [https://www.ebi.ac.uk/pdbsum/2rpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rpq ProSAT]</span></td></tr>
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{{STRUCTURE_2rpq| PDB=2rpq | SCENE= }}
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</table>
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== Function ==
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===Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3===
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[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[2rpq]] is a 2 chain structure of [[SUMO]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RPQ OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/2rpq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rpq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[SUMO]]
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ariyoshi, M.]]
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[[Category: Large Structures]]
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[[Category: Baba, D.]]
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[[Category: Ariyoshi M]]
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[[Category: Ikegami, T.]]
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[[Category: Baba D]]
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[[Category: Ikeguchi, M.]]
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[[Category: Ikegami T]]
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[[Category: Saitoh, H.]]
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[[Category: Ikeguchi M]]
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[[Category: Sekiyama, N.]]
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[[Category: Saitoh H]]
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[[Category: Shirakawa, M.]]
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[[Category: Sekiyama N]]
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[[Category: Tochio, H.]]
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[[Category: Shirakawa M]]
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[[Category: Uchimura, Y.]]
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[[Category: Tochio H]]
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[[Category: Yamane, T.]]
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[[Category: Uchimura Y]]
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[[Category: Activator]]
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[[Category: Yamane T]]
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[[Category: Alternative splicing]]
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[[Category: Coiled coil]]
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[[Category: Host-virus interaction]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Repressor]]
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[[Category: Sim]]
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[[Category: Sumo]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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Current revision

Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3

PDB ID 2rpq

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