1mtn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1mtn" [edit=sysop:move=sysop])
Current revision (07:02, 30 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mtn.png|left|200px]]
 
-
<!--
+
==BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION==
-
The line below this paragraph, containing "STRUCTURE_1mtn", creates the "Structure Box" on the page.
+
<StructureSection load='1mtn' size='340' side='right'caption='[[1mtn]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1mtn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MTN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1mtn| PDB=1mtn | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mtn OCA], [https://pdbe.org/1mtn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mtn RCSB], [https://www.ebi.ac.uk/pdbsum/1mtn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mtn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/1mtn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mtn ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of bovine alpha-chymotrypsin (alpha-CHT) in complex with the bovine basic pancreatic trypsin inhibitor (BPTI) has been solved and refined at 2.8 A resolution (R-factor = 0.18). The proteinase:inhibitor complex forms a compact dimer (two alpha-CHT and two BPTI molecules), which may be stabilized by surface-bound sulphate ions, in the crystalline state. Each BPTI molecule, at opposite ends, is contacting both proteinase molecules in the dimer, through the reactive site loop and through residues next to the inhibitor's C-terminal region. Specific recognition between alpha-CHT and BPTI occurs at the (re)active site interface according to structural rules inferred from the analysis of homologous serine proteinase:inhibitor complexes. Lys15, the P1 residue of BPTI, however, does not occupy the alpha-CHT S1 specificity pocket, being hydrogen bonded to backbone atoms of the enzyme surface residues Gly216 and Ser217.
-
===BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION===
+
Crystal structure of the bovine alpha-chymotrypsin:Kunitz inhibitor complex. An example of multiple protein:protein recognition sites.,Capasso C, Rizzi M, Menegatti E, Ascenzi P, Bolognesi M J Mol Recognit. 1997 Jan-Feb;10(1):26-35. PMID:9179777<ref>PMID:9179777</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9179777}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1mtn" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 9179777 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_9179777}}
+
-
 
+
-
==About this Structure==
+
-
[[1mtn]] is a 8 chain structure of [[Basic Pancreatic Trypsin Inhibitor]] and [[Chymotrypsin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTN OCA].
+
==See Also==
==See Also==
-
*[[Basic Pancreatic Trypsin Inhibitor]]
+
*[[BPTI 3D structures|BPTI 3D structures]]
-
*[[Chymotrypsin]]
+
*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:9179777</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Chymotrypsin]]
+
[[Category: Large Structures]]
-
[[Category: Ascenzi, P.]]
+
[[Category: Ascenzi P]]
-
[[Category: Bolognesi, M.]]
+
[[Category: Bolognesi M]]
-
[[Category: Capasso, C.]]
+
[[Category: Capasso C]]
-
[[Category: Menegatti, E.]]
+
[[Category: Menegatti E]]
-
[[Category: Rizzi, M.]]
+
[[Category: Rizzi M]]
-
[[Category: Complex]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Protease inhibitor]]
+
-
[[Category: Serine]]
+
-
[[Category: Trypsin]]
+

Current revision

BOVINE ALPHA-CHYMOTRYPSIN:BPTI CRYSTALLIZATION

PDB ID 1mtn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mtn"
Personal tools