3o3t

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[[Image:3o3t.png|left|200px]]
 
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==Crystal Structure Analysis of M32A mutant of human CLIC1==
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The line below this paragraph, containing "STRUCTURE_3o3t", creates the "Structure Box" on the page.
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<StructureSection load='3o3t' size='340' side='right'caption='[[3o3t]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ma4 3ma4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O3T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3t OCA], [https://pdbe.org/3o3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o3t RCSB], [https://www.ebi.ac.uk/pdbsum/3o3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3t ProSAT]</span></td></tr>
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{{STRUCTURE_3o3t| PDB=3o3t | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure Analysis of M32A mutant of human CLIC1===
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[3o3t]] is a 1 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ma4 3ma4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3T OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/3o3t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o3t ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels (Part II)]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Achilonu, I A.]]
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[[Category: Large Structures]]
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[[Category: Adamson, R J.]]
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[[Category: Achilonu IA]]
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[[Category: Dirr, H W.]]
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[[Category: Adamson RJ]]
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[[Category: Fanucchi, S.]]
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[[Category: Dirr HW]]
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[[Category: Fernandes, M A.]]
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[[Category: Fanucchi S]]
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[[Category: Stoychev, S.]]
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[[Category: Fernandes MA]]
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[[Category: Clic]]
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[[Category: Stoychev S]]
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[[Category: Domain interface]]
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[[Category: Glutathione transferase]]
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[[Category: Ion channel]]
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[[Category: Thioredoxin]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure Analysis of M32A mutant of human CLIC1

PDB ID 3o3t

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