1zp7

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[[Image:1zp7.png|left|200px]]
 
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==The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.==
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The line below this paragraph, containing "STRUCTURE_1zp7", creates the "Structure Box" on the page.
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<StructureSection load='1zp7' size='340' side='right'caption='[[1zp7]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZP7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zp7 OCA], [https://pdbe.org/1zp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zp7 RCSB], [https://www.ebi.ac.uk/pdbsum/1zp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zp7 ProSAT]</span></td></tr>
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{{STRUCTURE_1zp7| PDB=1zp7 | SCENE= }}
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</table>
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== Function ==
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===The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.===
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[https://www.uniprot.org/uniprot/RECU_BACSU RECU_BACSU] Has at least 2 separable functions; Holliday junction resolution with generation of monomeric chromosomes, and modulation of RecA activity. Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Partially inhibits the hydrolysis of dATP or rATP by RecA. Holliday junction resolution is stimulated by RuvB.<ref>PMID:14701911</ref> <ref>PMID:16020779</ref> <ref>PMID:16154091</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16154091 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/1zp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16154091}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zp7 ConSurf].
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[[1zp7]] is a 2 chain structure of [[Resolvase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP7 OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Resolvase]]
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*[[Resolvase 3D structures|Resolvase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16154091</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Alonso, J C.]]
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[[Category: Large Structures]]
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[[Category: Ayora, S.]]
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[[Category: Alonso JC]]
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[[Category: Carrasco, B.]]
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[[Category: Ayora S]]
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[[Category: McGregor, N.]]
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[[Category: Carrasco B]]
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[[Category: Rafferty, J.]]
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[[Category: McGregor N]]
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[[Category: Sedelnikova, S.]]
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[[Category: Rafferty J]]
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[[Category: Thaw, P.]]
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[[Category: Sedelnikova S]]
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[[Category: Dna binding protein]]
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[[Category: Thaw P]]
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[[Category: Dna-binding protein]]
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[[Category: Recombination]]
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[[Category: Resolvase]]
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Current revision

The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.

PDB ID 1zp7

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