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1n7i

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[[Image:1n7i.png|left|200px]]
 
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==The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046==
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The line below this paragraph, containing "STRUCTURE_1n7i", creates the "Structure Box" on the page.
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<StructureSection load='1n7i' size='340' side='right'caption='[[1n7i]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N7I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LY1:8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE'>LY1</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_1n7i| PDB=1n7i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7i OCA], [https://pdbe.org/1n7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n7i RCSB], [https://www.ebi.ac.uk/pdbsum/1n7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n7i ProSAT]</span></td></tr>
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</table>
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===The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046===
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== Function ==
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[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_14695818}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14695818 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/1n7i_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14695818}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1n7i]] is a 2 chain structure of [[Phenylethanolamine N-methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7I OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n7i ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phenylethanolamine N-methyltransferase]]
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*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:14695818</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phenylethanolamine N-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Archbold, J.]]
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[[Category: Archbold J]]
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[[Category: Caine, J M.]]
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[[Category: Caine JM]]
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[[Category: Criscione, K R.]]
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[[Category: Criscione KR]]
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[[Category: Grunewald, G L.]]
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[[Category: Grunewald GL]]
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[[Category: Martin, J L.]]
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[[Category: Martin JL]]
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[[Category: McLeish, M J.]]
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[[Category: McLeish MJ]]
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[[Category: McMillan, F M.]]
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[[Category: McMillan FM]]
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[[Category: Adrenaline]]
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[[Category: Catecholamine]]
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[[Category: Epinephrine]]
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[[Category: Methyltransferase]]
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[[Category: S-adenolsylhomocysteine]]
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[[Category: S-adenosylmethionine]]
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Current revision

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046

PDB ID 1n7i

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OCA

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