1wua

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[[Image:1wua.png|left|200px]]
 
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==The structure of Aplyronine A-actin complex==
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The line below this paragraph, containing "STRUCTURE_1wua", creates the "Structure Box" on the page.
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<StructureSection load='1wua' size='340' side='right'caption='[[1wua]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP8:(8R,9R,10R,11R,14S,18S,20S,24S)-24-{(1R,2S,3R,6R,7R,8R,9S,10E)-8-(ACETYLOXY)-6-[(N,N-DIMETHYLALANYL)OXY]-11-[FORMYL(METHYL)AMINO]-2-HYDROXY-1,3,7,9-TETRAMETHYLUNDEC-10-ENYL}-10-HYDROXY-14,20-DIMETHOXY-9,11,15,18-TETRAMETHYL-2-OXOOXACYCLOTETRACOSA-3,5,15,21-TETRAEN-8-YL+N,N,O-TRIMETHYLSERINATE'>AP8</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
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{{STRUCTURE_1wua| PDB=1wua | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wua OCA], [https://pdbe.org/1wua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wua RCSB], [https://www.ebi.ac.uk/pdbsum/1wua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wua ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aplyronine A, isolated from the sea hare Aplysia kurodai, possesses an exceedingly potent antitumor effect in vivo and it is one of the promising candidates as an anticancer drug. This macrolide is known to depolymerize F-actin and inhibit the polymerization of actin by forming a 1:1 complex with monomeric actin. The first complex structure of actin-aplyronine A was determined via a synchrotron X-ray analysis at a 1.45 A resolution. As expected, aplyronine A binds to a hydrophobic cleft composed of subdomains 1 and 3 of actin by intercalating its aliphatic tail part into the actin molecule as do the other reported F-actin depolymerizing agents. Unexpectedly, this complex structure shows the specific structural features around the trimethylserine moiety, revealed as an important moiety of aplyronine A for cytotoxicity against HeLa cells. Combining this result and our previous one, the moiety should strongly relate to the specific biological activity of aplyronine A; i.e. a potent antitumor effect.
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===The structure of Aplyronine A-actin complex===
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Structure basis for antitumor effect of aplyronine a.,Hirata K, Muraoka S, Suenaga K, Kuroda T, Kato K, Tanaka H, Yamamoto M, Takata M, Yamada K, Kigoshi H J Mol Biol. 2006 Mar 3;356(4):945-54. Epub 2005 Dec 27. PMID:16406066<ref>PMID:16406066</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_16406066}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wua" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16406066 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16406066}}
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==About this Structure==
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[[1wua]] is a 1 chain structure of [[Actin]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUA OCA].
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==See Also==
==See Also==
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*[[Actin]]
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*[[Actin 3D structures|Actin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16406066</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Hirata, K.]]
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[[Category: Hirata K]]
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[[Category: Kato, K.]]
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[[Category: Kato K]]
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[[Category: Kigoshi, H.]]
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[[Category: Kigoshi H]]
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[[Category: Kuroda, T.]]
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[[Category: Kuroda T]]
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[[Category: Muraoka, S.]]
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[[Category: Muraoka S]]
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[[Category: Suenaga, K.]]
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[[Category: Suenaga K]]
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[[Category: Takata, M.]]
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[[Category: Takata M]]
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[[Category: Tanaka, H.]]
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[[Category: Tanaka H]]
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[[Category: Yamada, K.]]
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[[Category: Yamada K]]
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[[Category: Yamamoto, M.]]
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[[Category: Yamamoto M]]
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[[Category: Aplyronine some]]
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[[Category: Macrolide]]
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[[Category: Marine sponge]]
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[[Category: Potent antitumor effect]]
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[[Category: Structural protein]]
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Current revision

The structure of Aplyronine A-actin complex

PDB ID 1wua

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