1r6p

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[[Image:1r6p.png|left|200px]]
 
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==NMR structure of the N-terminal domain of trout cardiac troponin C at 7 C==
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The line below this paragraph, containing "STRUCTURE_1r6p", creates the "Structure Box" on the page.
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<StructureSection load='1r6p' size='340' side='right'caption='[[1r6p]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1r6p| PDB=1r6p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6p OCA], [https://pdbe.org/1r6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6p RCSB], [https://www.ebi.ac.uk/pdbsum/1r6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7ZZB9_ONCMY Q7ZZB9_ONCMY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adaptation for life at different temperatures can cause changes in many aspects of an organism. One example is the expression of different protein isoforms in species adapted to different temperatures. The calcium regulatory protein cardiac troponin C (cTnC), from rainbow trout (Oncorhynchus mykiss), is a good model for studying temperature effects, both because of its low physiological temperature and because mammalian cTnC, extensively studied at higher temperatures, can be used for comparison. We determined the structure and studied the backbone dynamics of the regulatory domain of trout cardiac troponin C (ScNTnC) with one Ca(2+) bound at 7 and 30 degrees C, using nuclear magnetic resonance spectroscopy (NMR). The overall fold of the regulatory domain of trout cTnC at both temperatures is similar to the regulatory domain of mammalian (human, bovine, and porcine isoform) cTnC bound to one Ca(2+). By comparing the trout structures at the two temperatures, we identify differences between the positions of the helices flanking the calcium binding loops, and the overall structure at 7 degrees C is more compact than that at 30 degrees C. The structure at 7 degrees C is more similar to the mammalian cTnC, which was determined at 30 degrees C, indicating that they have the same conformation at their respective physiological temperatures. The dynamic properties of the regulatory domain of trout cTnC are similar at the two temperatures that were used in these studies.
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===NMR structure of the N-terminal domain of trout cardiac troponin C at 7 C===
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Effect of temperature on the structure of trout troponin C.,Blumenschein TM, Gillis TE, Tibbits GF, Sykes BD Biochemistry. 2004 May 4;43(17):4955-63. PMID:15109253<ref>PMID:15109253</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15109253}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1r6p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15109253 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15109253}}
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==About this Structure==
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[[1r6p]] is a 1 chain structure of [[Troponin]] with sequence from [http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6P OCA].
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==See Also==
==See Also==
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*[[Troponin]]
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*[[Troponin 3D structures|Troponin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:15109253</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oncorhynchus mykiss]]
[[Category: Oncorhynchus mykiss]]
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[[Category: Blumenschein, T M.]]
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[[Category: Blumenschein TM]]
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[[Category: Gillis, T E.]]
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[[Category: Gillis TE]]
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[[Category: Sykes, B D.]]
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[[Category: Sykes BD]]
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[[Category: Tibbits, G F.]]
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[[Category: Tibbits GF]]
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[[Category: Ef-hand]]
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[[Category: Metal binding protein]]
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Current revision

NMR structure of the N-terminal domain of trout cardiac troponin C at 7 C

PDB ID 1r6p

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