1syr

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[[Image:1syr.png|left|200px]]
 
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==Initial Structural Analysis of Plasmodium falciparum thioredoxin==
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The line below this paragraph, containing "STRUCTURE_1syr", creates the "Structure Box" on the page.
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<StructureSection load='1syr' size='340' side='right'caption='[[1syr]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1syr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SYR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syr OCA], [https://pdbe.org/1syr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1syr RCSB], [https://www.ebi.ac.uk/pdbsum/1syr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1syr ProSAT]</span></td></tr>
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{{STRUCTURE_1syr| PDB=1syr | SCENE= }}
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</table>
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== Function ==
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===Initial Structural Analysis of Plasmodium falciparum thioredoxin===
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[https://www.uniprot.org/uniprot/THIO1_PLAF7 THIO1_PLAF7] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:11013257, PubMed:20673832). By modifying the redox status of targeted proteins, induces changes in their structure and activity (PubMed:19360125, PubMed:20673832). Reduces oxidized glutathione (GSSG), thereby acting as a backup for the glutathione redox system (PubMed:11013257). Reduces nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO) (PubMed:11013257). Also reduces oxidative stress by detoxifying hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide (PubMed:14962358). Activates ornithine aminotransferase OAT by reducing a disulfide bond in the substrate binding loop, thereby enhancing the affinity of OAT for its substrates (PubMed:20673832). May reduce S-adenosyl-L-homocysteine hydrolase SAHH (PubMed:19360125).<ref>PMID:11013257</ref> <ref>PMID:14962358</ref> <ref>PMID:19360125</ref> <ref>PMID:20673832</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[1syr]] is a 12 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SYR OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sy/1syr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1syr ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thioredoxin]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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[[Category: Plasmodium falciparum 3d7]]
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== References ==
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[[Category: Hol, W G.J.]]
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<references/>
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[[Category: Robien, M A.]]
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__TOC__
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[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
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</StructureSection>
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[[Category: Protein structure initiative]]
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[[Category: Large Structures]]
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[[Category: Psi]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Sgpp]]
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[[Category: Hol WGJ]]
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[[Category: Structural genomic]]
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[[Category: Robien MA]]
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[[Category: Structural genomics of pathogenic protozoa consortium]]
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[[Category: Unknown function]]
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Current revision

Initial Structural Analysis of Plasmodium falciparum thioredoxin

PDB ID 1syr

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