3eb4

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[[Image:3eb4.png|left|200px]]
 
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==Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone==
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The line below this paragraph, containing "STRUCTURE_3eb4", creates the "Structure Box" on the page.
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<StructureSection load='3eb4' size='340' side='right'caption='[[3eb4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EB4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PDN:17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE'>PDN</scene></td></tr>
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{{STRUCTURE_3eb4| PDB=3eb4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb4 OCA], [https://pdbe.org/3eb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eb4 RCSB], [https://www.ebi.ac.uk/pdbsum/3eb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3eb4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eb4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Shaker family voltage-dependent potassium channels (Kv1) are expressed in a wide variety of cells and are essential for cellular excitability. In humans, loss-of-function mutations of Kv1 channels lead to hyperexcitability and are directly linked to episodic ataxia and atrial fibrillation. All Kv1 channels assemble with beta subunits (Kv betas), and certain Kv betas, for example Kv beta 1, have an N-terminal segment that closes the channel by the N-type inactivation mechanism. In principle, dissociation of Kv beta 1, although never reported, should eliminate inactivation and thus potentiate Kv1 current. We found that cortisone increases rat Kv1 channel activity by binding to Kv beta 1. A crystal structure of the Kv beta-cortisone complex was solved to 1.82-A resolution and revealed novel cortisone binding sites. Further studies demonstrated that cortisone promotes dissociation of Kv beta. The new mode of channel modulation may be explored by native or synthetic ligands to fine-tune cellular excitability.
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===Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone===
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Cortisone dissociates the Shaker family K+ channels from their beta subunits.,Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, Zhou M Nat Chem Biol. 2008 Nov;4(11):708-14. Epub 2008 Sep 21. PMID:18806782<ref>PMID:18806782</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18806782}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3eb4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18806782 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18806782}}
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==About this Structure==
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[[3eb4]] is a 1 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB4 OCA].
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==See Also==
==See Also==
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*[[Ion channels]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18806782</ref><ref group="xtra">PMID:10399921</ref><ref group="xtra">PMID:10884227</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bhosle, R C.]]
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[[Category: Bhosle RC]]
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[[Category: Cao, Y.]]
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[[Category: Cao Y]]
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[[Category: Kabaleeswaran, V.]]
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[[Category: Kabaleeswaran V]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Pan, Y.]]
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[[Category: Pan Y]]
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[[Category: Weng, J.]]
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[[Category: Weng J]]
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[[Category: Zhou, M.]]
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[[Category: Zhou M]]
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[[Category: Cortisone]]
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[[Category: Cytoplasm]]
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[[Category: Interface]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Kvbeta]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Potassium]]
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[[Category: Potassium transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Voltage-gated channel]]
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Current revision

Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone

PDB ID 3eb4

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