1zyq

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[[Image:1zyq.png|left|200px]]
 
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==T7 DNA polymerase in complex with 8oG and incoming ddATP==
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The line below this paragraph, containing "STRUCTURE_1zyq", creates the "Structure Box" on the page.
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<StructureSection load='1zyq' size='340' side='right'caption='[[1zyq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=DAD:2,3-DIDEOXYADENOSINE-5-TRIPHOSPHATE'>DAD</scene>, <scene name='pdbligand=DDG:2,3-DIDEOXY-GUANOSINE-5-MONOPHOSPHATE'>DDG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1zyq| PDB=1zyq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyq OCA], [https://pdbe.org/1zyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyq RCSB], [https://www.ebi.ac.uk/pdbsum/1zyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyq ProSAT]</span></td></tr>
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</table>
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===T7 DNA polymerase in complex with 8oG and incoming ddATP===
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_BPT7 DPOL_BPT7] Replicates viral genomic DNA. Non-processive DNA polymerase that achieves processivity by binding to host thioredoxin (TrxA). This interaction increases the rate of dNTP incorporation to yield a processivity of approximately 800 nucleotides (nt) per binding event. Interacts with DNA helicase gp4 to coordinate nucleotide polymerization with unwinding of the DNA. The leading strand is synthesized continuously while synthesis of the lagging strand requires the synthesis of oligoribonucleotides by the primase domain of gp4.<ref>PMID:9218486</ref> <ref>PMID:21606333</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16271888}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16271888 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyq_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16271888}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1zyq]] is a 4 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYQ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zyq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thioredoxin]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:16271888</ref><references group="xtra"/>
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<references/>
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[[Category: DNA-directed DNA polymerase]]
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__TOC__
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[[Category: Enterobacteria phage t7]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bebenek, K.]]
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[[Category: Escherichia phage T7]]
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[[Category: Brieba, L G.]]
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[[Category: Large Structures]]
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[[Category: Ellenberger, T.]]
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[[Category: Bebenek K]]
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[[Category: Kokoska, R J.]]
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[[Category: Brieba LG]]
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[[Category: Kunkel, T A.]]
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[[Category: Ellenberger T]]
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[[Category: 8og]]
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[[Category: Kokoska RJ]]
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[[Category: Fidelity]]
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[[Category: Kunkel TA]]
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[[Category: Transferase/electron transport/dna complex]]
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Current revision

T7 DNA polymerase in complex with 8oG and incoming ddATP

PDB ID 1zyq

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OCA

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