1gme

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1gme" [edit=sysop:move=sysop])
Current revision (08:49, 9 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1gme.png|left|200px]]
 
-
<!--
+
==Crystal structure and assembly of an eukaryotic small heat shock protein==
-
The line below this paragraph, containing "STRUCTURE_1gme", creates the "Structure Box" on the page.
+
<StructureSection load='1gme' size='340' side='right'caption='[[1gme]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1gme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GME FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gme OCA], [https://pdbe.org/1gme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gme RCSB], [https://www.ebi.ac.uk/pdbsum/1gme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gme ProSAT]</span></td></tr>
-
{{STRUCTURE_1gme| PDB=1gme | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HS16B_WHEAT HS16B_WHEAT]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gme_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gme ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The 2.7 A structure of wheat HSP16.9, a member of the small heat shock proteins (sHSPs), indicates how its alpha-crystallin domain and flanking extensions assemble into a dodecameric double disk. The folding of the monomer and assembly of the oligomer are mutually interdependent, involving strand exchange, helix swapping, loose knots and hinged extensions. In support of the chaperone mechanism, the substrate-bound dimers, in temperature-dependent equilibrium with higher assembly forms, have unfolded N-terminal arms and exposed conserved hydrophobic binding sites on the alpha-crystallin domain. The structure also provides a model by which members of the sHSP protein family bind unfolded substrates, which are involved in a variety of neurodegenerative diseases and cataract formation.
-
===CRYSTAL STRUCTURE AND ASSEMBLY OF AN EUKARYOTIC SMALL HEAT SHOCK PROTEIN===
+
Crystal structure and assembly of a eukaryotic small heat shock protein.,van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E Nat Struct Biol. 2001 Dec;8(12):1025-30. PMID:11702068<ref>PMID:11702068</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11702068}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1gme" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11702068 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_11702068}}
+
-
 
+
-
==About this Structure==
+
-
[[1gme]] is a 4 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GME OCA].
+
==See Also==
==See Also==
-
*[[Heat Shock Proteins]]
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:11702068</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Triticum aestivum]]
[[Category: Triticum aestivum]]
-
[[Category: Basha, E.]]
+
[[Category: Basha E]]
-
[[Category: Friedrich, K L.]]
+
[[Category: Friedrich KL]]
-
[[Category: Montfort, R L.M Van.]]
+
[[Category: Slingsby C]]
-
[[Category: Slingsby, C.]]
+
[[Category: Van Montfort RLM]]
-
[[Category: Vierling, E.]]
+
[[Category: Vierling E]]
-
[[Category: Alpha-crystallin]]
+
-
[[Category: Chaperone]]
+
-
[[Category: Small heat shock protein]]
+

Current revision

Crystal structure and assembly of an eukaryotic small heat shock protein

PDB ID 1gme

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gme"
Personal tools