This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jmc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2jmc" [edit=sysop:move=sysop])
Current revision (10:06, 20 December 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jmc.png|left|200px]]
 
-
<!--
+
==Chimer between Spc-SH3 and P41==
-
The line below this paragraph, containing "STRUCTURE_2jmc", creates the "Structure Box" on the page.
+
<StructureSection load='2jmc' size='340' side='right'caption='[[2jmc]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMC FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmc OCA], [https://pdbe.org/2jmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmc RCSB], [https://www.ebi.ac.uk/pdbsum/2jmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmc ProSAT]</span></td></tr>
-
{{STRUCTURE_2jmc| PDB=2jmc | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jmc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jmc ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Here we present the high-resolution NMR structure of a chimera (SPCp41) between alpha-spectrin SH3 domain and the decapeptide p41. The tertiary structure mimics perfectly the interactions typically found in SH3-peptide complexes and is remarkably similar to that of the complex between the separate Spc-SH3 domain and ligand p41. Relaxation data confirm the tight binding between the ligand and SH3 part of the chimera. This chimera will serve as a tool for a deeper understanding of the relationship between structure and thermodynamics of binding using a combination of NMR, stability and site-directed mutagenesis studies, which can lead to an effective strategy for ligand design.
-
===Chimer between Spc-SH3 and P41===
+
The high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complex.,Candel AM, Conejero-Lara F, Martinez JC, van Nuland NA, Bruix M FEBS Lett. 2007 Feb 20;581(4):687-92. Epub 2007 Jan 22. PMID:17275816<ref>PMID:17275816</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17275816}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2jmc" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17275816 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_17275816}}
+
-
 
+
-
==About this Structure==
+
-
[[2jmc]] is a 1 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA].
+
==See Also==
==See Also==
-
*[[Spectrin]]
+
*[[Spectrin 3D structures|Spectrin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:17275816</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
-
[[Category: Bruix, M.]]
+
[[Category: Large Structures]]
-
[[Category: Candel, A M.]]
+
[[Category: Bruix M]]
-
[[Category: Conejero-Lara, F.]]
+
[[Category: Candel AM]]
-
[[Category: Martinez, J C.]]
+
[[Category: Conejero-Lara F]]
-
[[Category: Nuland, N A.J van.]]
+
[[Category: Martinez JC]]
-
[[Category: Chimer]]
+
[[Category: Van Nuland NAJ]]
-
[[Category: P41]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Spc-sh3]]
+

Current revision

Chimer between Spc-SH3 and P41

PDB ID 2jmc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jmc"
Personal tools