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3ch8

From Proteopedia

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[[Image:3ch8.png|left|200px]]
 
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==The crystal structure of PDZ-Fibronectin fusion protein==
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The line below this paragraph, containing "STRUCTURE_3ch8", creates the "Structure Box" on the page.
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<StructureSection load='3ch8' size='340' side='right'caption='[[3ch8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ch8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CH8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3ch8| PDB=3ch8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch8 OCA], [https://pdbe.org/3ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch8 ProSAT]</span></td></tr>
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</table>
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===The crystal structure of PDZ-Fibronectin fusion protein===
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== Function ==
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[https://www.uniprot.org/uniprot/ERBIN_HUMAN ERBIN_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).<ref>PMID:10878805</ref> <ref>PMID:16203728</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19646997}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19646997 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19646997}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3ch8]] is a 2 chain structure of [[Fibronectin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ch8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Fibronectin]]
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*[[Fibronectin 3D structures|Fibronectin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19646997</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Huang, J.]]
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[[Category: Large Structures]]
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[[Category: Koide, A.]]
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[[Category: Huang J]]
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[[Category: Koide, S.]]
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[[Category: Koide A]]
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[[Category: Makabe, K.]]
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[[Category: Koide S]]
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[[Category: Fibronectin]]
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[[Category: Makabe K]]
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[[Category: Pdz]]
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[[Category: Structural protein]]
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Current revision

The crystal structure of PDZ-Fibronectin fusion protein

PDB ID 3ch8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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