1auc

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[[Image:1auc.png|left|200px]]
 
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==HUMAN THIOREDOXIN (OXIDIZED WITH DIAMIDE)==
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The line below this paragraph, containing "STRUCTURE_1auc", creates the "Structure Box" on the page.
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<StructureSection load='1auc' size='340' side='right'caption='[[1auc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1auc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AUC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1auc OCA], [https://pdbe.org/1auc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1auc RCSB], [https://www.ebi.ac.uk/pdbsum/1auc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1auc ProSAT]</span></td></tr>
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{{STRUCTURE_1auc| PDB=1auc | SCENE= }}
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</table>
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== Function ==
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===HUMAN THIOREDOXIN (OXIDIZED WITH DIAMIDE)===
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[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_9369469}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9369469 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/1auc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9369469}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1auc ConSurf].
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[[1auc]] is a 1 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AUC OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thioredoxin]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:9369469</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, J F.]]
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[[Category: Large Structures]]
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[[Category: Gasdaska, J.]]
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[[Category: Anderson JF]]
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[[Category: Montfort, W R.]]
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[[Category: Gasdaska J]]
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[[Category: Powis, G.]]
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[[Category: Montfort WR]]
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[[Category: Sanders, D A.R.]]
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[[Category: Powis G]]
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[[Category: Weichsel, A.]]
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[[Category: Sanders DAR]]
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[[Category: Dimer]]
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[[Category: Weichsel A]]
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[[Category: Electron transport]]
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[[Category: Oxidoreductase]]
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[[Category: Thioredoxin]]
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[[Category: X-ray crystallography]]
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Current revision

HUMAN THIOREDOXIN (OXIDIZED WITH DIAMIDE)

PDB ID 1auc

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OCA

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