3iko

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[[Image:3iko.png|left|200px]]
 
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==Crystal structure of the heterotrimeric Sec13-Nup145C-Nup84 nucleoporin complex==
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The line below this paragraph, containing "STRUCTURE_3iko", creates the "Structure Box" on the page.
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<StructureSection load='3iko' size='340' side='right'caption='[[3iko]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iko]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IKO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iko OCA], [https://pdbe.org/3iko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iko RCSB], [https://www.ebi.ac.uk/pdbsum/3iko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iko ProSAT]</span></td></tr>
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{{STRUCTURE_3iko| PDB=3iko | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the heterotrimeric Sec13-Nup145C-Nup84 nucleoporin complex===
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[https://www.uniprot.org/uniprot/SEC13_YEAST SEC13_YEAST] Functions as a component of the nuclear pore complex (NPC) and the COPII coat. It is one of 5 proteins constituting the COPII coat, which is involved in anterograde (ER to Golgi) double-membrane transport vesicle formation. First the small GTPase SAR1, activated by and binding to the integral ER membrane protein SEC12, exchanges GDP for GTP and recruits the heterodimer SEC23/24, which in turn recruits the heterotetramer SEC13-SEC31. The polymerization of COPII coat complexes then causes physically the deformation (budding) of the membrane, leading to the creation of a transport vesicle. The COPII complex is dissociated upon SAR1-GTP hydrolysis to SAR1-GDP. SEC23 functions as the SAR1 GTPase activating protein, whose activity is stimulated in the presence of SEC13/31. SEC13 is directly or indirectly required for normal ER membrane and nuclear envelope morphology. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.<ref>PMID:8565072</ref> <ref>PMID:6996832</ref> <ref>PMID:7026045</ref> <ref>PMID:2188733</ref> <ref>PMID:8548805</ref> <ref>PMID:8909535</ref> <ref>PMID:9409822</ref> <ref>PMID:9199164</ref> <ref>PMID:9427388</ref> <ref>PMID:9023343</ref> <ref>PMID:10720463</ref> <ref>PMID:10747086</ref> <ref>PMID:11535824</ref> <ref>PMID:11717432</ref> <ref>PMID:12215173</ref> <ref>PMID:11823431</ref> <ref>PMID:12475940</ref> <ref>PMID:14627716</ref> <ref>PMID:21454883</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19805193 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3iko_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iko ConSurf].
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[[3iko]] is a 9 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKO OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19805193</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Blobel, G.]]
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[[Category: Blobel G]]
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[[Category: Davenport, A.]]
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[[Category: Davenport A]]
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[[Category: Debler, E W.]]
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[[Category: Debler EW]]
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[[Category: Hoelz, A.]]
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[[Category: Hoelz A]]
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[[Category: Hsia, K C.]]
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[[Category: Hsia K-C]]
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[[Category: Nagy, V.]]
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[[Category: Nagy V]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Mrna transport]]
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[[Category: Npc]]
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[[Category: Nuclear pore complex]]
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[[Category: Nuclear protein]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Rna-binding]]
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[[Category: Structural protein]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Wd repeat]]
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Current revision

Crystal structure of the heterotrimeric Sec13-Nup145C-Nup84 nucleoporin complex

PDB ID 3iko

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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