1zho

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[[Image:1zho.png|left|200px]]
 
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==The structure of a ribosomal protein L1 in complex with mRNA==
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The line below this paragraph, containing "STRUCTURE_1zho", creates the "Structure Box" on the page.
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<StructureSection load='1zho' size='340' side='right'caption='[[1zho]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zho]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZHO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1zho| PDB=1zho | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zho OCA], [https://pdbe.org/1zho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zho RCSB], [https://www.ebi.ac.uk/pdbsum/1zho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zho ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL1_THETH RL1_THETH] The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/1zho_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zho ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RNA-binding ability of ribosomal protein L1 is of profound interest, since L1 has a dual function as a ribosomal structural protein that binds rRNA and as a translational repressor that binds its own mRNA. Here, we report the crystal structure at 2.6 A resolution of ribosomal protein L1 from the bacterium Thermus thermophilus in complex with a 38 nt fragment of L1 mRNA from Methanoccocus vannielii. The conformation of RNA-bound T.thermophilus L1 differs dramatically from that of the isolated protein. Analysis of four copies of the L1-mRNA complex in the crystal has shown that domain II of the protein does not contribute to mRNA-specific binding. A detailed comparison of the protein-RNA interactions in the L1-mRNA and L1-rRNA complexes identified amino acid residues of L1 crucial for recognition of its specific targets on the both RNAs. Incorporation of the structure of bacterial L1 into a model of the Escherichia coli ribosome revealed two additional contact regions for L1 on the 23S rRNA that were not identified in previous ribosome models.
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===The structure of a ribosomal protein L1 in complex with mRNA===
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New insights into the interaction of ribosomal protein L1 with RNA.,Nevskaya N, Tishchenko S, Volchkov S, Kljashtorny V, Nikonova E, Nikonov O, Nikulin A, Kohrer C, Piendl W, Zimmermann R, Stockley P, Garber M, Nikonov S J Mol Biol. 2006 Jan 27;355(4):747-59. Epub 2005 Nov 17. PMID:16330048<ref>PMID:16330048</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16330048}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zho" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16330048 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16330048}}
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==About this Structure==
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[[1zho]] is a 8 chain structure of [[Ribosomal protein L1]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHO OCA].
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==See Also==
==See Also==
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*[[Ribosomal protein L1]]
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*[[Ribosomal protein L1|Ribosomal protein L1]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16330048</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Garber, M.]]
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[[Category: Garber M]]
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[[Category: Kljashtorny, V.]]
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[[Category: Kljashtorny V]]
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[[Category: Kohrer, C.]]
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[[Category: Kohrer C]]
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[[Category: Nevskaya, N.]]
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[[Category: Nevskaya N]]
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[[Category: Nikonov, O.]]
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[[Category: Nikonov O]]
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[[Category: Nikonov, S.]]
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[[Category: Nikonov S]]
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[[Category: Nikonova, E.]]
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[[Category: Nikonova E]]
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[[Category: Nikulin, A.]]
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[[Category: Nikulin A]]
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[[Category: Piendl, W.]]
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[[Category: Piendl W]]
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[[Category: Stockley, P.]]
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[[Category: Stockley P]]
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[[Category: Tishchenko, S.]]
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[[Category: Tishchenko S]]
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[[Category: Volchkov, S.]]
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[[Category: Volchkov S]]
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[[Category: Zimmermann, R.]]
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[[Category: Zimmermann R]]
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[[Category: L1]]
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[[Category: Mrna-protein complex]]
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[[Category: Regulation of gene expression]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Rna-protein interaction]]
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[[Category: Structural protein/rna complex]]
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Current revision

The structure of a ribosomal protein L1 in complex with mRNA

PDB ID 1zho

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